| Title | Amyloid-β Deposition and Long-Term Progression in Mild Cognitive Impairment due to Alzheimer's Disease Defined with Amyloid PET Imaging. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Hatashita, S, Wakebe, D |
| Journal | J Alzheimers Dis |
| Volume | 57 |
| Issue | 3 |
| Pagination | 765-773 |
| Date Published | 2017 |
| ISSN | 1875-8908 |
| Keywords | Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Aniline Compounds, Cognitive Dysfunction, Disease Progression, Female, Follow-Up Studies, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Mental Status Schedule, Middle Aged, Positron-Emission Tomography, Thiazoles |
| Abstract | The aim was to evaluate brain amyloid-β (Aβ) deposition in patients with mild cognitive impairment (MCI) due to Alzheimer's disease (AD) using amyloid PET imaging and clarify the relationship between the annual change in Aβ deposition and disease progression. Forty-eight MCI patients underwent neuropsychological assessment and amyloid PET imaging using [11C]-PIB over a follow-up of 5.7±1.5 years. Thirty-nine MCI patients who had an amyloid-positive scan were defined as MCI due to AD, and 9 MCI patients who had an amyloid-negative scan were included. Regions of interest were defined on co-registered MRI, and the PIB standardized uptake value ratio (SUVR) on the same regions was used over follow-up. Annual change in PIB SUVR was calculated. Patients with MCI due to AD had higher baseline PIB SUVR (1.81±0.32, n = 39, p |
| DOI | 10.3233/JAD-161074 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 28304292 |
