Journal of Alzheimer's Disease
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Home > Raman Spectrometric Detection Methods for Early and Non-Invasive Diagnosis of Alzheimer's Disease.

TitleRaman Spectrometric Detection Methods for Early and Non-Invasive Diagnosis of Alzheimer's Disease.
Publication TypeJournal Article
Year of Publication2017
AuthorsHuang, C-C, Isidoro, C
JournalJ Alzheimers Dis
Volume57
Issue4
Pagination1145-1156
Date Published2017
ISSN1875-8908
Abstract

The continuous increasing rate of patients suffering of Alzheimer's disease (AD) worldwide requires the adoption of novel techniques for non-invasive early diagnosis and monitoring of the disease. Here we review the various Raman spectroscopic techniques, including Fourier Transform-Raman spectroscopy, surface-enhanced Raman scattering spectroscopy, coherent anti-Stokes Raman scattering spectroscopy, and confocal Raman microspectroscopy, that could be used for the diagnosis of AD. These techniques have shown the potential to detect AD biomarkers, such as the amyloid-β peptide and the tau protein, or the neurotransmitters involved in the disease (e.g., Glutamate and γ-Aminobutyric acid), or the typical structural alterations in specific brain areas. The possibility to detect the specific biomarkers in liquid biopsies and to obtain high resolution 3D microscope images of the affected area make the Raman spectroscopy a valuable ally in the early diagnosis and monitoring of AD.

DOI10.3233/JAD-161238
Alternate JournalJ. Alzheimers Dis.
PubMed ID28304304
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Source URL: https://www.j-alz.com/content/raman-spectrometric-detection-methods-early-and-non-invasive-diagnosis-%C2%A0alzheimers-disease