Title | Biomarkers and Functional Decline in Prodromal Alzheimer's Disease. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Robb, C, Udeh-Momoh, C, Wagenpfeil, S, Schöpe, J, Alexopoulos, P, Perneczky, R |
Corporate Authors | Alzheimer’s Disease Neuroimaging Initiative |
Journal | J Alzheimers Dis |
Volume | 58 |
Issue | 1 |
Pagination | 69-78 |
Date Published | 2017 |
ISSN | 1875-8908 |
Abstract | BACKGROUND: Little is known of possible associations between Alzheimer's disease (AD) biomarkers and instrumental activities of daily living (IADL) change over time. OBJECTIVE: The present study seeks to identify relationships between baseline imaging and fluid biomarker profiles, and decline in IADL utilizing data collated from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. METHODS: Generalized estimating equations analysis, adjusted for cognitive deterioration, was applied to a cohort of 509 individuals from all stages of ADNI, including 156 healthy controls, 189 early mild cognitive impairment (MCI) patients and 164 MCI patients. RESULTS: A significant correlation was found between baseline biomarkers, specifically CSF Aβ and FDG PET, and IADL change over a 3-year period in individuals with MCI. Importantly, comparable correlations between presence of pathological biomarker levels and temporal decline in both functional and cognitive performance were also noted. DISCUSSION: We show that distinct baseline biomarkers may predict latent changes in IADL. Our results necessitate a revision of the commonly held view upholding cognitive changes as the predominant endpoint measure associated with presence of abnormal baseline biomarkers. |
DOI | 10.3233/JAD-161162 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 28372331 |