Title | Modifiable Risk Factors for Prevention of Dementia in Midlife, Late Life and the Oldest-Old: Validation of the LIBRA Index. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Vos, SJB, van Boxtel, MPJ, Schiepers, OJG, Deckers, K, de Vugt, M, Carrière, I, Dartigues, J-F, Pérès, K, Artero, S, Ritchie, K, Galluzzo, L, Scafato, E, Frisoni, GB, Huisman, M, Comijs, HC, Sacuiu, SF, Skoog, I, Irving, K, O'Donnell, CA, Verhey, FRJ, Visser, PJelle, Köhler, S |
Journal | J Alzheimers Dis |
Volume | 58 |
Issue | 2 |
Pagination | 537-547 |
Date Published | 2017 |
ISSN | 1875-8908 |
Abstract | BACKGROUND: Recently, the LIfestyle for BRAin health (LIBRA) index was developed to assess an individual's prevention potential for dementia. OBJECTIVE: We investigated the predictive validity of the LIBRA index for incident dementia in midlife, late life, and the oldest-old. METHODS: 9,387 non-demented individuals were recruited from the European population-based DESCRIPA study. An individual's LIBRA index was calculated solely based on modifiable risk factors: depression, diabetes, physical activity, hypertension, obesity, smoking, hypercholesterolemia, coronary heart disease, and mild/moderate alcohol use. Cox regression was used to test the predictive validity of LIBRA for dementia at follow-up (mean 7.2 y, range 1-16). RESULTS: In midlife (55-69 y, n = 3,256) and late life (70-79 y, n = 4,320), the risk for dementia increased with higher LIBRA scores. Individuals in the intermediate- and high-risk groups had a higher risk of dementia than those in the low-risk group. In the oldest-old (80-97 y, n = 1,811), higher LIBRA scores did not increase the risk for dementia. CONCLUSION: LIBRA might be a useful tool to identify individuals for primary prevention interventions of dementia in midlife, and maybe in late life, but not in the oldest-old. |
DOI | 10.3233/JAD-161208 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 28453475 |