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Home > Modifiable Risk Factors for Prevention of Dementia in Midlife, Late Life and the Oldest-Old: Validation of the LIBRA Index.

TitleModifiable Risk Factors for Prevention of Dementia in Midlife, Late Life and the Oldest-Old: Validation of the LIBRA Index.
Publication TypeJournal Article
Year of Publication2017
AuthorsVos, SJB, van Boxtel, MPJ, Schiepers, OJG, Deckers, K, de Vugt, M, Carrière, I, Dartigues, J-F, Pérès, K, Artero, S, Ritchie, K, Galluzzo, L, Scafato, E, Frisoni, GB, Huisman, M, Comijs, HC, Sacuiu, SF, Skoog, I, Irving, K, O'Donnell, CA, Verhey, FRJ, Visser, PJelle, Köhler, S
JournalJ Alzheimers Dis
Volume58
Issue2
Pagination537-547
Date Published2017
ISSN1875-8908
Abstract

BACKGROUND: Recently, the LIfestyle for BRAin health (LIBRA) index was developed to assess an individual's prevention potential for dementia.

OBJECTIVE: We investigated the predictive validity of the LIBRA index for incident dementia in midlife, late life, and the oldest-old.

METHODS: 9,387 non-demented individuals were recruited from the European population-based DESCRIPA study. An individual's LIBRA index was calculated solely based on modifiable risk factors: depression, diabetes, physical activity, hypertension, obesity, smoking, hypercholesterolemia, coronary heart disease, and mild/moderate alcohol use. Cox regression was used to test the predictive validity of LIBRA for dementia at follow-up (mean 7.2 y, range 1-16).

RESULTS: In midlife (55-69 y, n = 3,256) and late life (70-79 y, n = 4,320), the risk for dementia increased with higher LIBRA scores. Individuals in the intermediate- and high-risk groups had a higher risk of dementia than those in the low-risk group. In the oldest-old (80-97 y, n = 1,811), higher LIBRA scores did not increase the risk for dementia.

CONCLUSION: LIBRA might be a useful tool to identify individuals for primary prevention interventions of dementia in midlife, and maybe in late life, but not in the oldest-old.

DOI10.3233/JAD-161208
Alternate JournalJ. Alzheimers Dis.
PubMed ID28453475
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