Title | Vitamin D Insufficiency and Cognitive Function Trajectories in Older Adults: The Rancho Bernardo Study. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Laughlin, GA, Kritz-Silverstein, D, Bergstrom, J, Reas, ET, Jassal, SK, Barrett-Connor, E, McEvoy, LK |
Journal | J Alzheimers Dis |
Volume | 58 |
Issue | 3 |
Pagination | 871-883 |
Date Published | 2017 |
ISSN | 1875-8908 |
Abstract | BACKGROUND: Evidence of a role for vitamin D (VitD) in cognitive aging is mixed and based primarily on extreme VitD deficiency. We evaluated the association of VitD insufficiency with cognitive function in older, community-dwelling adults living in a temperate climate with year-round sunshine. METHODS: A population-based longitudinal study of 1,058 adults (median age 75; 62% women) who had cognitive function assessed and serum levels of 25-hydroxyvitaminD (25OHD) measured in 1997-99 and were followed for up to three additional cognitive function assessments over a 12-year period. RESULTS: Overall, 14% (nā=ā145) of participants had VitD insufficiency defined as 25OHD CONCLUSION: In this population with little VitD deficiency, even moderately low VitD was associated with poorer performance on multiple domains of cognitive function. Low VitD did not predict 12-year cognitive decline. Clinical trials are essential to establish a causal link between VitD and cognitive well-being. |
DOI | 10.3233/JAD-161295 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 28505973 |