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Home > Vitamin D Insufficiency and Cognitive Function Trajectories in Older Adults: The Rancho Bernardo Study.

TitleVitamin D Insufficiency and Cognitive Function Trajectories in Older Adults: The Rancho Bernardo Study.
Publication TypeJournal Article
Year of Publication2017
AuthorsLaughlin, GA, Kritz-Silverstein, D, Bergstrom, J, Reas, ET, Jassal, SK, Barrett-Connor, E, McEvoy, LK
JournalJ Alzheimers Dis
Volume58
Issue3
Pagination871-883
Date Published2017
ISSN1875-8908
Abstract

BACKGROUND: Evidence of a role for vitamin D (VitD) in cognitive aging is mixed and based primarily on extreme VitD deficiency. We evaluated the association of VitD insufficiency with cognitive function in older, community-dwelling adults living in a temperate climate with year-round sunshine.

METHODS: A population-based longitudinal study of 1,058 adults (median age 75; 62% women) who had cognitive function assessed and serum levels of 25-hydroxyvitaminD (25OHD) measured in 1997-99 and were followed for up to three additional cognitive function assessments over a 12-year period.

RESULTS: Overall, 14% (nā€Š=ā€Š145) of participants had VitD insufficiency defined as 25OHD

CONCLUSION: In this population with little VitD deficiency, even moderately low VitD was associated with poorer performance on multiple domains of cognitive function. Low VitD did not predict 12-year cognitive decline. Clinical trials are essential to establish a causal link between VitD and cognitive well-being.

DOI10.3233/JAD-161295
Alternate JournalJ. Alzheimers Dis.
PubMed ID28505973
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