| Title | Neuropsychiatric Symptoms and Alzheimer's Disease Biomarkers Predict Driving Decline: Brief Report. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Babulal, GM, Stout, SH, Head, D, Holtzman, DM, Fagan, AM, Morris, JC, Roe, CM |
| Journal | J Alzheimers Dis |
| Volume | 58 |
| Issue | 3 |
| Pagination | 675-680 |
| Date Published | 2017 |
| ISSN | 1875-8908 |
| Abstract | We examined whether neuropsychiatric symptoms (NPS) interact with cerebrospinal fluid (CSF) biomarkers (amyloid-β42 [Aβ42], tau, phosphorylated tau181 [ptau181], tau/Aβ42, and ptau181/Aβ42) of Alzheimer's disease pathology to predict driving decline among cognitively-normal older adults (N = 116) aged ≥65. Cox proportional hazards models examined time to receiving a rating of marginal or fail on the driving test. Age, education, and gender were adjusted in the models. Participants with more abnormal CSF (Aβ42, tau/Aβ42, ptau181/Aβ42) and NPS were faster to receive a marginal/fail on the road test compared to those without NPS. NPS interact with abnormal CSF biomarkers to impact driving performance among cognitively-normal older adults. |
| DOI | 10.3233/JAD-170067 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 28453487 |
| PubMed Central ID | PMC5555740 |
| Grant List | P01 AG003991 / AG / NIA NIH HHS / United States P01 AG026276 / AG / NIA NIH HHS / United States P50 AG005681 / AG / NIA NIH HHS / United States R01 AG043434 / AG / NIA NIH HHS / United States |
