| Title | Increased Plasma Homocysteine Level is Associated with Executive Dysfunction in Type 2 Diabetic Patients with Mild Cognitive Impairment. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Tian, S, Han, J, Huang, R, Sun, J, Cai, R, Shen, Y, Wang, S |
| Journal | J Alzheimers Dis |
| Volume | 58 |
| Issue | 4 |
| Pagination | 1163-1173 |
| Date Published | 2017 |
| ISSN | 1875-8908 |
| Abstract | BACKGROUND: Homocysteine (Hcy) is involved in the pathogenesis of type 2 diabetes mellitus (T2DM) and Alzheimer's disease. OBJECTIVE: We aimed to investigate the role of Hcy in T2DM patients with mild cognitive impairment (MCI), and to determine whether methylene tetrahydrofolate reductase (MTHFR) C677T or cystathionine beta-synthase (CBS) 844ins68 polymorphism is related to T2DM-associated MCI. METHODS: We recruited 285 T2DM patients and divided them into two groups, 140 patients with MCI, and 145 healthy-cognition controls, on the basis of Montreal Cognitive Assessment (MoCA) scores. Demographic characteristics, clinical parameters, and neuropsychological tests were assessed. MTHFR C677T and CBS 844ins68 polymorphisms were analyzed. RESULTS: The MCI group exhibited significantly higher plasma total Hcy (tHcy) levels than control group (p CONCLUSION: Increased plasma tHcy level was significantly related to T2DM-associated MCI, especially executive dysfunction. Further investigation with a large population size should be conducted to confirm these findings. |
| DOI | 10.3233/JAD-170162 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 28550262 |
