Title | Cortical Thickness and Depressive Symptoms in Cognitively Normal Individuals: The Mayo Clinic Study of Aging. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Pink, A, Przybelski, SA, Krell-Roesch, J, Stokin, GB, Roberts, RO, Mielke, MM, Knopman, DS, Jack, CR, Petersen, RC, Geda, YE |
Journal | J Alzheimers Dis |
Volume | 58 |
Issue | 4 |
Pagination | 1273-1281 |
Date Published | 2017 |
ISSN | 1875-8908 |
Abstract | Altered cortical thickness has been observed in aging and various neurodegenerative disorders. Furthermore, reduced hippocampal volume has been reported in late-life depression. Even mild depressive symptoms are common in the elderly. However, little is known about the structural MRI measures of depressive symptoms in normal cognitive aging. Thus we sought to examine the association between depressive symptoms with cortical thickness and hippocampal volume as measured by brain MRI among community-dwelling participants. We conducted a cross-sectional study derived from the ongoing population-based Mayo Clinic Study of Aging, involving cognitively normal participants (N = 1,507) aged≥70 years. We observed that depressive symptoms were associated with lower global cortical thickness and lower thickness in specific prefrontal and temporal cortical regions, labeled by FreeSurfer software, version 5.3. As expected, the strength of correlation was very small, given that participants were community-dwelling with only mild depressive symptoms. We did not observe associations between hippocampal volume and depressive symptoms. These findings may provide insight into the structural correlates of mild depressive symptoms in elderly participants. |
DOI | 10.3233/JAD-170041 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 28550256 |
PubMed Central ID | PMC5713905 |
Grant List | K01 MH068351 / MH / NIMH NIH HHS / United States R01 AG041851 / AG / NIA NIH HHS / United States R01 AG034676 / AG / NIA NIH HHS / United States U01 AG024904 / AG / NIA NIH HHS / United States R01 AG011378 / AG / NIA NIH HHS / United States R01 AG037551 / AG / NIA NIH HHS / United States R01 AG043392 / AG / NIA NIH HHS / United States K01 AG028573 / AG / NIA NIH HHS / United States U01 AG006786 / AG / NIA NIH HHS / United States |