Title | Exploring Potential Electrophysiological Biomarkers in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of Event-Related Potential Studies. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Gu, L, Zhang, Z |
Journal | J Alzheimers Dis |
Volume | 58 |
Issue | 4 |
Pagination | 1283-1292 |
Date Published | 2017 |
ISSN | 1875-8908 |
Abstract | BACKGROUND: Early diagnosis and effective management are pivotal steps in preventing the transition from mild cognitive impairment (MCI) to Alzheimer's disease. Previous investigations indicated that some event-related potential (ERP) components in MCI are sensitive to cognitive decline. However, several comparative analyses of these components in MCI and healthy controls (HC) yielded inconsistent results. OBJECTIVE: The aim was to perform a systematic review and meta-analysis of ERP studies on MCI patients. METHODS: We systematically searched on PubMed and Web of Science for MCI-related ERP studies published from April 1986 to August 2016. Standard mean difference estimates of all components were compared between MCI and HC. RESULTS: Our study showed increased P50 amplitude at the Cz site; reduced N2pc amplitude and delayed P200 latency at the Cz site; N200 latency at the Cz and Pz sites, and P300 latency at the Cz and Pz sites in MCI patients compared to HC. CONCLUSIONS: In summary, our study indicated that some ERP components, such as P50 and N2pc amplitude, P200, N200, and P300 latency might be potential electrophysiological biomarkers for MCI diagnosis. |
DOI | 10.3233/JAD-161286 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 28550252 |