| Title | Combustion-Derived Nanoparticles in Key Brain Target Cells and Organelles in Young Urbanites: Culprit Hidden in Plain Sight in Alzheimer's Disease Development. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | González-Maciel, A, Reynoso-Robles, R, Torres-Jardón, R, Mukherjee, PS, Calderón-Garcidueñas, L |
| Journal | J Alzheimers Dis |
| Volume | 59 |
| Issue | 1 |
| Pagination | 189-208 |
| Date Published | 2017 |
| ISSN | 1875-8908 |
| Abstract | Millions of children and young adults are exposed to fine particulate matter (PM2.5) and ozone, associated with Alzheimer's disease (AD) risk. Mexico City (MC) children exhibit systemic and brain inflammation, low cerebrospinal fluid (CSF) Aβ1-42, breakdown of nasal, olfactory, alveolar-capillary, duodenal, and blood-brain barriers, volumetric and metabolic brain changes, attention and short-term memory deficits, and hallmarks of AD and Parkinson's disease. Airborne iron-rich strongly magnetic combustion-derived nanoparticles (CDNPs) are present in young urbanites' brains. Using transmission electron microscopy, we documented CDNPs in neurons, glia, choroid plexus, and neurovascular units of young MC residents versus matched clean air controls. CDNPs are associated with pathology in mitochondria, endoplasmic reticulum (ER), mitochondria-ER contacts (MERCs), axons,and dendrites. There is a significant difference in size and numbers between spherical CDNPs (>85%) and the angular, euhedral endogenous NPs ( |
| DOI | 10.3233/JAD-170012 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 28598844 |
