Title | No Genetic Overlap Between Circulating Iron Levels and Alzheimer's Disease. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Lupton, MK, Benyamin, B, Proitsi, P, Nyholt, DR, Ferreira, MA, Montgomery, GW, Heath, AC, Madden, PA, Medland, SE, Gordon, SD, Lovestone, S, Tsolaki, M, Kloszewska, I, Soininen, H, Mecocci, P, Vellas, B, Powell, JF, Bush, AI, Wright, MJ, Martin, NG, Whitfield, JB |
Corporate Authors | GERAD1 Consortium, Alzheimer’s Disease Neuroimaging Initiative |
Journal | J Alzheimers Dis |
Volume | 59 |
Issue | 1 |
Pagination | 85-99 |
Date Published | 2017 |
ISSN | 1875-8908 |
Abstract | Iron deposition in the brain is a prominent feature of Alzheimer's disease (AD). Recently, peripheral iron measures have also been shown to be associated with AD status. However, it is not known whether these associations are causal: do elevated or depleted iron levels throughout life have an effect on AD risk? We evaluate the effects of peripheral iron on AD risk using a genetic profile score approach by testing whether variants affecting iron, transferrin, or ferritin levels selected from GWAS meta-analysis of approximately 24,000 individuals are also associated with AD risk in an independent case-control cohort (n∼10,000). Conversely, we test whether AD risk variants from a GWAS meta-analysis of approximately 54,000 account for any variance in iron measures (n∼9,000). We do not identify a genetic relationship, suggesting that peripheral iron is not causal in the initiation of AD pathology. |
DOI | 10.3233/JAD-170027 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 28582860 |