Title | Reduced Cerebrospinal Fluid Concentration of Apolipoprotein A-I in Patients with Alzheimer's Disease. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Johansson, P, Almqvist, EG, Bjerke, M, Wallin, A, Johansson, J-O, Andreasson, U, Blennow, K, Zetterberg, H, Svensson, J |
Journal | J Alzheimers Dis |
Volume | 59 |
Issue | 3 |
Pagination | 1017-1026 |
Date Published | 2017 |
ISSN | 1875-8908 |
Abstract | BACKGROUND: Apolipoprotein E (ApoE) has been extensively studied in Alzheimer's disease (AD), but little is known of apolipoprotein A-I (ApoA-I) in cerebrospinal fluid (CSF). OBJECTIVE: Plasma lipids as well as ApoA-I and ApoE in plasma and CSF were determined and related to Mini-Mental State Examination (MMSE) score, APOE genotype, and CSF AD biomarkers. METHODS: Consecutive patients with AD (n = 29), stable mild cognitive impairment (n = 13), other dementias (n = 14), and healthy controls (n = 18) were included at a single center. RESULTS: AD patients had higher plasma triglycerides and lower CSF ApoA-I concentration than controls (both p CONCLUSION: CSF ApoA-I was reduced in AD patients and associated with measures of cognitive function and AD disease status. The mechanisms underlying the decreased CSF:plasma ratios of ApoA-I and ApoE in AD and other dementias need to be explored in further studies. |
DOI | 10.3233/JAD-170226 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 28697566 |