Title | Autonomic Cardiac Function in Preclinical Alzheimer's Disease. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Santos, CY, Machan, JT, Wu, W-C, Snyder, PJ |
Journal | J Alzheimers Dis |
Volume | 59 |
Issue | 3 |
Pagination | 1057-1065 |
Date Published | 2017 |
ISSN | 1875-8908 |
Abstract | To explore early autonomic cardiac changes in pre-clinical Alzheimer's disease (AD), we have evaluated electrocardiologic measures of vagal tone for 63 adults (ages 55-75) at rest, during cognitive testing, and then again at rest. All subjects had multiple risk factors for AD, and all completed amyloid PET scans (18F-Florbetapir) to determine amyloid positivity (Aβ+). No change in electrocardiographic measures were observed for Aβ+ participants under each testing condition, whereas Aβ-subjects showed an expected increase in vagal tone during the cognitive stress condition. These findings suggest an early relationship between cortical Aβ accumulation, a precursor to AD development, and autonomic cardiac function. |
DOI | 10.3233/JAD-170217 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 28697563 |
Grant List | U54 GM115677 / GM / NIGMS NIH HHS / United States |