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Home > Classification of Alzheimer's Disease and Prediction of Mild Cognitive Impairment Conversion Using Histogram-Based Analysis of Patient-Specific Anatomical Brain Connectivity Networks.

TitleClassification of Alzheimer's Disease and Prediction of Mild Cognitive Impairment Conversion Using Histogram-Based Analysis of Patient-Specific Anatomical Brain Connectivity Networks.
Publication TypeJournal Article
Year of Publication2017
AuthorsBeheshti, I, Maikusa, N, Daneshmand, M, Matsuda, H, Demirel, H, Anbarjafari, G
Corporate AuthorsJapanese-Alzheimer’s Disease Neuroimaging Initiative
JournalJ Alzheimers Dis
Volume60
Issue1
Pagination295-304
Date Published2017
ISSN1875-8908
Abstract

In this study, we investigated the early detection of Alzheimer's disease (AD) and mild cognitive impairment (MCI) conversion to AD through individual structural connectivity networks using structural magnetic resonance imaging (sMRI) data. In the proposed method, the cortical morphometry of individual gray matter images were used to construct structural connectivity networks. A statistical feature generation approach based on histogram-based feature generation procedure was proposed to represent a statistical-pattern of connectivity networks from a high-dimensional space into low-dimensional feature vectors. The proposed method was evaluated on numerous samples including 61 healthy controls (HC), 42 stable-MCI (sMCI), 45 progressive-MCI (pMCI), and 83 AD subjects at the baseline from the J-ADNI data-set using support vector machine classifier. The proposed method yielded a classification accuracy of 84.17%, 70.38%, and 61.05% in identifying AD/HC, MCIs/HCs, and sMCI/pMCI, respectively. The experimental results show that the proposed method performed in a comparable way to alternative methods using MRI data.

DOI10.3233/JAD-161080
Alternate JournalJ. Alzheimers Dis.
PubMed ID28800325
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