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Home > Plasma Amyloid-β Levels, Cerebral Small Vessel Disease, and Cognition: The Rotterdam Study.

TitlePlasma Amyloid-β Levels, Cerebral Small Vessel Disease, and Cognition: The Rotterdam Study.
Publication TypeJournal Article
Year of Publication2017
AuthorsHilal, S, Akoudad, S, van Duijn, CM, Niessen, WJ, Verbeek, MM, Vanderstichele, H, Stoops, E, M Ikram, A, Vernooij, MW
JournalJ Alzheimers Dis
Volume60
Issue3
Pagination977-987
Date Published2017
ISSN1875-8908
Abstract

BACKGROUND: Plasma amyloid-β (Aβ) levels are increasingly studied as a potential, accessible marker of cognitive impairment and dementia. The most common plasma Aβ isoforms, i.e., Aβ1-40 and Aβ1-42 have been linked with risk of Alzheimer's disease. However, it remains under-explored whether plasma Aβ levels including novel Aβ1-38 relate to vascular brain disease and cognition in a preclinical-phase of dementiaObjective:To examine the association of plasma Aβ levels (i.e., Aβ1-38, Aβ1-40, and Aβ1-42) with markers of cerebral small vessel disease (SVD) and cognition in a large population-based setting.

METHODS: We analyzed plasma Aβ1 levels in 1201 subjects from two independent cohorts of the Rotterdam Study. Markers of SVD [lacunes, white matter hyperintensity (WMH) volume] were assessed on brain MRI (1.5T). Cognition was assessed by a detailed neuropsychological battery. In each cohort, the association of Aβ levels with SVD and cognition was performed using regression models. Estimates were then pooled across cohorts using inverse variance meta-analysis with fixed effects.

RESULTS: Higher levels of plasma Aβ1-38, Aβ1-40, Aβ1-42, and Aβ1-40/ Aβ1-42 ratio were associated with increasing lacunar and microbleeds counts. Moreover, higher levels of Aβ1-40 and Aβ1-40/ Aβ1-42 were significantly associated with larger WMH volumes. With regard to cognition, a higher level of Aβ1-38 Aβ1-40 and Aβ1-40/ Aβ1-42 was related to worse performance on cognitive test specifically in memory domain.

CONCLUSION: Higher plasma levels of Aβ levels are associated with subclinical markers of vascular disease and poorer memory. Plasma Aβ levels thus mark the presence of vascular brain pathology.

DOI10.3233/JAD-170458
Alternate JournalJ. Alzheimers Dis.
PubMed ID28984600
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Source URL: https://www.j-alz.com/content/plasma-amyloid-%CE%B2-levels-cerebral-small-vessel-disease-and-cognition-rotterdam-study