| Title | Low Prevalence and Clinical Effect of Vascular Risk Factors in Early-Onset Alzheimer's Disease. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Chen, Y, Sillaire, ARollin, Dallongeville, J, Skrobala, E, Wallon, D, Dubois, B, Hannequin, D, Pasquier, F |
| Corporate Authors | Lille YOD study group |
| Journal | J Alzheimers Dis |
| Volume | 60 |
| Issue | 3 |
| Pagination | 1045-1054 |
| Date Published | 2017 |
| ISSN | 1875-8908 |
| Abstract | BACKGROUND: Determinants of early-onset Alzheimer's disease (EOAD) are not well known. In late-onset AD, vascular risk factors (VRFs) are associated with earlier clinical manifestation. OBJECTIVE: The objective of this study was to assess the putative association between VRFs and EOAD. METHODS: We studied participants with dementia meeting criteria for EOAD (recruited into the French CoMAJ prospective cohort study from 1 June 2009 to 28 February 2014) and age-, gender-matched controls (ratio 1:3, drawn randomly from the French MONA-LISA population-based survey between 2005 and 2007). Demographic data, VRFs, comorbidities, treatments, and APOE genotypes were compared in multivariable logistic regression analyses. RESULTS: We studied 102 participants with dementia (mean±standard deviation age: 59.5±3.8; women: 59.8%) and 306 controls. Compared with controls, EOAD participants had spent less time in formal education (9.9±2.9 versus 11.7±3.8 y; p CONCLUSION: The prevalence of VRFs is not elevated in EOAD patients (in contrast to older AD patients). Extensive genetic testing should be considered more frequently in the context of EOAD. |
| DOI | 10.3233/JAD-170367 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 28984595 |
| PubMed Central ID | PMC5676853 |
