| Title | Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Kim, M, Nevado-Holgado, A, Whiley, L, Snowden, SG, Soininen, H, Kloszewska, I, Mecocci, P, Tsolaki, M, Vellas, B, Thambisetty, M, Dobson, RJB, Powell, JF, Lupton, MK, Simmons, A, Velayudhan, L, Lovestone, S, Proitsi, P, Legido-Quigley, C |
| Journal | J Alzheimers Dis |
| Volume | 60 |
| Issue | 3 |
| Pagination | 809-817 |
| Date Published | 2017 |
| ISSN | 1875-8908 |
| Abstract | Lipids such as ceramides and phosphatidylcholines (PC) have been found altered in the plasma of Alzheimer's disease (AD) patients in a number of discovery studies. For this reason, the levels of 6 ceramides and 3 PCs, with different fatty acid length and saturation levels, were measured in the plasma from 412 participants (AD n = 205, Control n = 207) using mass spectrometry coupled with ultra-performance liquid chromatography. After this, associations with AD status, brain atrophy, and age-related effects were studied. In the plasma of AD participants, cross-sectional analysis revealed elevated levels of three ceramides (Cer16:0 p 75, p |
| DOI | 10.3233/JAD-160645 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 27911300 |
| PubMed Central ID | PMC5676755 |
| Grant List | / / Wellcome Trust / United Kingdom |
