Journal of Alzheimer's Disease
Published on Journal of Alzheimer's Disease (https://www.j-alz.com)

Home > Biological Factors Contributing to the Response to Cognitive Training in Mild Cognitive Impairment.

TitleBiological Factors Contributing to the Response to Cognitive Training in Mild Cognitive Impairment.
Publication TypeJournal Article
Year of Publication2018
AuthorsPeter, J, Schumacher, LV, Landerer, V, Abdulkadir, A, Kaller, CP, Lahr, J, Klöppel, S
JournalJ Alzheimers Dis
Volume61
Issue1
Pagination333-345
Date Published2018
ISSN1875-8908
KeywordsAged, Aged, 80 and over, Analysis of Variance, Apolipoproteins E, Biological Factors, Cognitive Behavioral Therapy, Cognitive Dysfunction, Entorhinal Cortex, Female, Follow-Up Studies, Functional Laterality, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Mental Recall, Middle Aged, Neuropsychological Tests, Reaction Time, Spatial Navigation, Treatment Outcome
Abstract

In mild cognitive impairment (MCI), small benefits from cognitive training were observed for memory functions but there appears to be great variability in the response to treatment. Our study aimed to improve the characterization and selection of those participants who will benefit from cognitive intervention. We evaluated the predictive value of disease-specific biological factors for the outcome after cognitive training in MCI (n = 25) and also considered motivation of the participants. We compared the results of the cognitive intervention group with two independent control groups of MCI patients (local memory clinic, n = 20; ADNI cohort, n = 302). The primary outcome measure was episodic memory as measured by verbal delayed recall of a 10-word list. Episodic memory remained stable after treatment and slightly increased 6 months after the intervention. In contrast, in MCI patients who did not receive an intervention, episodic memory significantly decreased during the same time interval. A larger left entorhinal cortex predicted more improvement in episodic memory after treatment and so did higher levels of motivation. Adding disease-specific biological factors significantly improved the prediction of training-related change compared to a model based simply on age and baseline performance. Bootstrapping with resampling (n = 1000) verified the stability of our finding. Cognitive training might be particularly helpful in individuals with a bigger left entorhinal cortex as individuals who did not benefit from intervention showed 17% less volume in this area. When extended to alternative treatment options, stratification based on disease-specific biological factors is a useful step towards individualized medicine.

DOI10.3233/JAD-170580
Alternate JournalJ. Alzheimers Dis.
PubMed ID29154279
PubMed Central IDPMC5734129
Grant ListU01 AG024904 / AG / NIA NIH HHS / United States
E-mail Icon
Comment Icon
  • Comment
Bookmark Icon Bookmark Recommend Icon Recommend Follow Icon Follow
  • Comment
| Bookmark | Recommend | Follow

Source URL: https://www.j-alz.com/content/biological-factors-contributing-response-cognitive-training-mild-cognitive-impairment