Title | Association between α-Klotho and Deep White Matter Lesions in the Brain: A Pilot Case Control Study Using Brain MRI. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Kuriyama, N, Ozaki, E, Mizuno, T, Ihara, M, Mizuno, S, Koyama, T, Matsui, D, Watanabe, I, Akazawa, K, Takeda, K, Takada, A, Inaba, M, Yamada, S, Motoyama, K, Takeshita, W, Iwai, K, Hashiguchi, K, Kobayashi, D, Kondo, M, Tamura, A, Yamada, K, Nakagawa, M, Watanabe, Y |
Journal | J Alzheimers Dis |
Volume | 61 |
Issue | 1 |
Pagination | 145-155 |
Date Published | 2018 |
ISSN | 1875-8908 |
Keywords | Aged, Aged, 80 and over, Apolipoprotein E4, Brain, C-Reactive Protein, Case-Control Studies, Cognition Disorders, Female, Glucuronidase, Humans, Image Processing, Computer-Assisted, Leukoencephalopathies, Magnetic Resonance Imaging, Male, Mental Status Schedule, Middle Aged, Neuropsychological Tests, Pilot Projects, Severity of Illness Index |
Abstract | BACKGROUND: The anti-aging protein, α-Klotho, may be involved in cognitive decline and has potential as a surrogate marker that reflects dementia. However, the role of α-Klotho in the brain has not been sufficiently investigated. OBJECTIVE: Here, we investigated the association between α-Klotho and cognitive decline that is associated with cerebral deep white matter lesions (DWMLs). METHODS: Two hundred-eighty participants (187 males and 93 females, mean age: 70.8 years old) were evaluated for DWMLs, and the Fazekas scale (Grade) was assessed following brain magnetic resonance imaging. A questionnaire concerning lifestyle and neuropsychological tests was administered, and their associations with the blood α-Klotho level were retrospectively investigated. RESULTS: The α-Klotho level was 685.1 pg/mL in Grade 0 (68 subjects), 634.1 in G1 (134), 596.0 in G2 (62), and 571.6 in G3 (16), showing that the level significantly decreased with advanced grades. Significant correlations were noted between the α-Klotho level and higher brain function tests including the Mini-Mental State Examination and word fluency tests (p CONCLUSION: A reduced blood α-Klotho level was correlated with grading of cerebral DWMLs and was accompanied by cognitive decline as an independent risk factor. The α-Klotho level may serve as a useful clinical index of vascular cognitive impairment. |
DOI | 10.3233/JAD-170466 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 29154273 |