Title | Comparison between FCSRT and LASSI-L to Detect Early Stage Alzheimer's Disease. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Matías-Guiu, JA, Cabrera-Martín, MNieves, Curiel, RE, Valles-Salgado, M, Rognoni, T, Moreno-Ramos, T, Carreras, JLuis, Loewenstein, DA, Matías-Guiu, J |
Journal | J Alzheimers Dis |
Volume | 61 |
Issue | 1 |
Pagination | 103-111 |
Date Published | 2018 |
ISSN | 1875-8908 |
Keywords | Aged, Aged, 80 and over, Alzheimer Disease, Cues, Female, Fluorodeoxyglucose F18, Humans, Male, Memory Disorders, Mental Recall, Middle Aged, Neuropsychological Tests, Positron-Emission Tomography, Psychiatric Status Rating Scales, ROC Curve, Semantics |
Abstract | BACKGROUND: The Free and Cued Selective Reminding Test (FCSRT) is the most accurate test for the diagnosis of prodromal Alzheimer's disease (AD). Recently, a novel cognitive test, the Loewenstein-Acevedo Scale for Semantic Interference and Learning (LASSI-L), has been developed in order to provide an early diagnosis. OBJECTIVE: To compare the diagnostic accuracy of the FCSRT and the LASSI-L for the diagnosis of AD in its preclinical and prodromal stages using 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) as a reference. METHODS: Fifty patients consulting for subjective memory complaints without functional impairment and at risk for AD were enrolled and evaluated using FCSRT, LASSI-L, and FDG-PET. Participants were evaluated using a comprehensive neurological and neuropsychological protocol and were assessed with the FCSRT and LASSI-L. FDG-PET was acquired concomitantly and used for classification of patients as AD or non-AD according to brain metabolism using both visual and semi-quantitative methods. RESULTS: LASSI-L scores allowed a better classification of patients as AD/non-AD in comparison to FCSRT. Logistic regression analysis showed delayed recall and failure to recovery from proactive semantic interference from LASSI-L as independent statistically significant predictors, obtaining an area under the curve of 0.894. This area under the curve provided a better discrimination than the best FCSRT score (total delayed recall, area under the curve 0.708, p = 0.029). CONCLUSIONS: The LASSI-L, a cognitive stress test, was superior to FCSRT in the prediction of AD features on FDG-PET. This emphasizes the possibility to advance toward an earlier diagnosis of AD from a clinical perspective. |
DOI | 10.3233/JAD-170604 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 29125488 |
PubMed Central ID | PMC6320221 |
Grant List | R01 AG047649 / AG / NIA NIH HHS / United States |