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Home > Economic Burden, Mortality, and Institutionalization in Patients Newly Diagnosed with Alzheimer's Disease.

TitleEconomic Burden, Mortality, and Institutionalization in Patients Newly Diagnosed with Alzheimer's Disease.
Publication TypeJournal Article
Year of Publication2018
AuthorsBlack, CM, Fillit, H, Xie, L, Hu, X, M Kariburyo, F, Ambegaonkar, BM, Baser, O, Yuce, H, Khandker, RK
JournalJ Alzheimers Dis
Volume61
Issue1
Pagination185-193
Date Published2018
ISSN1875-8908
KeywordsAged, Aged, 80 and over, Alzheimer Disease, Cohort Studies, Comorbidity, Cost of Illness, Female, Humans, Institutionalization, Male, Neuropsychological Tests
Abstract

BACKGROUND: Current information is scarce regarding comorbid conditions, treatment, survival, institutionalization, and health care utilization for Alzheimer's disease (AD) patients.

OBJECTIVES: Compare all-cause mortality, rate of institutionalization, and economic burden between treated and untreated newly-diagnosed AD patients.

METHODS: Patients aged 65-100 years with ≥1 primary or ≥2 secondary AD diagnoses (ICD-9-CM:331.0] with continuous medical and pharmacy benefits for ≥12 months pre-index and ≥6 months post-index date (first AD diagnosis date) were identified from Medicare fee-for-service claims 01JAN2011-30JUN2014. Patients with AD treatment claims or AD/AD-related dementia diagnosis during the pre-index period were excluded. Patients were assigned to treated and untreated cohorts based on AD treatment received post-index date. Total 8,995 newly-diagnosed AD patients were identified; 4,037 (44.8%) were assigned to the treated cohort. Time-to-death and institutionalization were assessed using Cox regression. To compare health care costs and utilizations, 1 : 1 propensity score matching (PSM) was used.

RESULTS: Untreated patients were older (83.85 versus 81.44 years; p 

CONCLUSION: After controlling for comorbidities, treated AD patients have better survival, lower institutionalization, and sometimes fewer resource utilizations, suggesting that treatment and improved care management could be beneficial for newly-diagnosed AD patients from economic and clinical perspectives.

DOI10.3233/JAD-170518
Alternate JournalJ. Alzheimers Dis.
PubMed ID29103033
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Source URL: https://www.j-alz.com/content/economic-burden-mortality-and-institutionalization-patients-newly-diagnosed-alzheimers