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Home > Co-Expression of Glia Maturation Factor and Apolipoprotein E4 in Alzheimer's Disease Brain.

TitleCo-Expression of Glia Maturation Factor and Apolipoprotein E4 in Alzheimer's Disease Brain.
Publication TypeJournal Article
Year of Publication2018
AuthorsThangavel, R, Bhagavan, SM, Ramaswamy, SBeladakere, Surpur, S, Govindarajan, R, Kempuraj, D, Zaheer, S, Raikwar, S, Ahmed, ME, Selvakumar, GPushpavath, Iyer, SS, Zaheer, A
JournalJ Alzheimers Dis
Volume61
Issue2
Pagination553-560
Date Published2018
ISSN1875-8908
KeywordsAlzheimer Disease, Amyloid beta-Peptides, Apolipoprotein E4, Brain, Case-Control Studies, Fluorescent Antibody Technique, Glia Maturation Factor, Humans, Neurofibrillary Tangles, Plaque, Amyloid
Abstract

Apolipoprotein E4 (ApoE4) is a major genetic risk factor for Alzheimer's disease (AD). The E4 allele of ApoE plays a crucial role in the inflammatory and neurodegenerative processes associated with AD. This is evident from the multiple effects of the ApoE isoforms in amyloid-β (Aβ) aggregation. Glia maturation factor (GMF) is a brain-specific neuroinflammatory protein that we have previously demonstrated to be significantly upregulated in various regions of AD brains compared to non-AD control brains and that it induces neurodegeneration. We have previously reported that GMF is predominantly expressed in the reactive astrocytes surrounding amyloid plaques (APs) in AD brain. In the present study, using immunohistochemical and dual immunofluorescence staining, we show the expression and colocalization of GMF and ApoE4 in AD brains. Our results show that ApoE4 is present within the APs of AD brain. Further, we found that GMF and ApoE4 were strongly expressed and co-associated in APs and in the reactive astrocytes surrounding APs in AD. An increased expression of GMF in APs and neurofibrillary tangles in the AD brain, and the co-localization of GMF and ApoE4 in APs suggest that GMF and ApoE4 together should be contributing to the neuropathological changes associated with AD.

DOI10.3233/JAD-170777
Alternate JournalJ. Alzheimers Dis.
PubMed ID29172001
PubMed Central IDPMC5770144
Grant ListI01 BX002477 / BX / BLRD VA / United States
R01 AG048205 / AG / NIA NIH HHS / United States
R01 NS073670 / NS / NINDS NIH HHS / United States
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Source URL: https://www.j-alz.com/content/co-expression-glia-maturation-factor-and-apolipoprotein-e4-alzheimers-disease-brain