Title | Tau and Amyloid Positron Emission Tomography Imaging Predict Driving Performance Among Older Adults with and without Preclinical Alzheimer's Disease. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Roe, CM, Babulal, GM, Mishra, S, Gordon, BA, Stout, SH, Ott, BR, Carr, DB, Ances, BM, Morris, JC, Benzinger, TLS |
Journal | J Alzheimers Dis |
Volume | 61 |
Issue | 2 |
Pagination | 509-513 |
Date Published | 2018 |
ISSN | 1875-8908 |
Keywords | Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Automobile Driving, Biomarkers, Carbolines, Female, Humans, Logistic Models, Male, Neuroimaging, Positron-Emission Tomography, tau Proteins |
Abstract | Abnormal levels of Alzheimer's disease (AD) biomarkers, measured by positron emission tomography imaging using amyloid-based radiotracers and cerebrospinal fluid, are associated with impaired driving performance in older adults. We examined whether preclinical AD staging, defined using amyloid imaging and tau imaging using the radiotracer T807 (AKA flortaucipir or AV-1451), was associated with receiving a marginal/fail rating on a standardized road test (nā=ā42). Participants at Stage 2 (positive amyloid and tau scans) of preclinical AD were more likely to receive a marginal/fail rating compared to participants at Stage 0 or 1. Stage 2 preclinical AD may manifest in worse driving performance. |
DOI | 10.3233/JAD-170521 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 29171997 |
PubMed Central ID | PMC5784441 |
Grant List | R01 AG043434 / AG / NIA NIH HHS / United States P01 AG003991 / AG / NIA NIH HHS / United States P50 AG005681 / AG / NIA NIH HHS / United States P01 AG026276 / AG / NIA NIH HHS / United States R01 AG054567 / AG / NIA NIH HHS / United States UL1 TR002345 / TR / NCATS NIH HHS / United States R01 AG056466 / AG / NIA NIH HHS / United States |