Title | Cerebrospinal Fluid C-C Motif Chemokine Ligand 2 Correlates with Brain Atrophy and Cognitive Impairment in Alzheimer's Disease. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Kimura, A, Yoshikura, N, Hayashi, Y, Inuzuka, T |
Journal | J Alzheimers Dis |
Volume | 61 |
Issue | 2 |
Pagination | 581-588 |
Date Published | 2018 |
ISSN | 1875-8908 |
Keywords | Aged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Peptides, Atrophy, Biomarkers, Chemokine CCL2, Cognitive Dysfunction, Disease Progression, Female, Gray Matter, Humans, Linear Models, Magnetic Resonance Imaging, Male, Neuropsychological Tests, tau Proteins, Temporal Lobe |
Abstract | BACKGROUND: Chronic neuroinflammation has been implicated in Alzheimer's disease (AD) pathology. OBJECTIVE: To investigate the association between cytokine and anti-amyloid-β (Aβ) autoantibody levels and the degree of brain atrophy and cognitive impairment in AD patients. METHODS: Cerebrospinal fluid (CSF) levels of C-C motif chemokine ligand 2 (CCL2), C-X-C motif chemokine ligand 8, C-X-C motif chemokine ligand 10, interleukin 6, and anti-Aβ autoantibody were evaluated in 69 AD patients. Serum levels of CCL2 and anti-Aβ autoantibody were also examined. The degree of brain atrophy was assessed using the voxel-based specific regional analysis system for AD, which targets the volumes of interest (VOI) in medial temporal structures. Cognitive function was evaluated by neuropsychological testing, including the Mini-Mental State Examination (MMSE) and Frontal Assessment Battery (FAB). RESULTS: CSF CCL2 levels correlated significantly with the severity (p = 0.023) and the extent (p = 0.022) of VOI atrophy, and with the extent of gray matter atrophy (p = 0.039) in AD patients. CSF anti-Aβ autoantibody levels were inversely correlated with the severity of VOI atrophy (p = 0.020), the extent of VOI atrophy (p = 0.015), and the ratio of VOI/GM atrophy (r = -0.358, p = 0.004). CSF CCL2 levels were also inversely correlated with MMSE (p = 0.0497) and FAB scores (p = 0.016). CONCLUSIONS: CSF CCL2 levels are associated with the degree of medial temporal lobe and gray matter atrophy, and cognitive decline in AD. |
DOI | 10.3233/JAD-170519 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 29171996 |