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Home > Cerebrospinal Fluid C-C Motif Chemokine Ligand 2 Correlates with Brain Atrophy and Cognitive Impairment in Alzheimer's Disease.

TitleCerebrospinal Fluid C-C Motif Chemokine Ligand 2 Correlates with Brain Atrophy and Cognitive Impairment in Alzheimer's Disease.
Publication TypeJournal Article
Year of Publication2018
AuthorsKimura, A, Yoshikura, N, Hayashi, Y, Inuzuka, T
JournalJ Alzheimers Dis
Volume61
Issue2
Pagination581-588
Date Published2018
ISSN1875-8908
KeywordsAged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Peptides, Atrophy, Biomarkers, Chemokine CCL2, Cognitive Dysfunction, Disease Progression, Female, Gray Matter, Humans, Linear Models, Magnetic Resonance Imaging, Male, Neuropsychological Tests, tau Proteins, Temporal Lobe
Abstract

BACKGROUND: Chronic neuroinflammation has been implicated in Alzheimer's disease (AD) pathology.

OBJECTIVE: To investigate the association between cytokine and anti-amyloid-β (Aβ) autoantibody levels and the degree of brain atrophy and cognitive impairment in AD patients.

METHODS: Cerebrospinal fluid (CSF) levels of C-C motif chemokine ligand 2 (CCL2), C-X-C motif chemokine ligand 8, C-X-C motif chemokine ligand 10, interleukin 6, and anti-Aβ autoantibody were evaluated in 69 AD patients. Serum levels of CCL2 and anti-Aβ autoantibody were also examined. The degree of brain atrophy was assessed using the voxel-based specific regional analysis system for AD, which targets the volumes of interest (VOI) in medial temporal structures. Cognitive function was evaluated by neuropsychological testing, including the Mini-Mental State Examination (MMSE) and Frontal Assessment Battery (FAB).

RESULTS: CSF CCL2 levels correlated significantly with the severity (p = 0.023) and the extent (p = 0.022) of VOI atrophy, and with the extent of gray matter atrophy (p = 0.039) in AD patients. CSF anti-Aβ autoantibody levels were inversely correlated with the severity of VOI atrophy (p = 0.020), the extent of VOI atrophy (p = 0.015), and the ratio of VOI/GM atrophy (r = -0.358, p = 0.004). CSF CCL2 levels were also inversely correlated with MMSE (p = 0.0497) and FAB scores (p = 0.016).

CONCLUSIONS: CSF CCL2 levels are associated with the degree of medial temporal lobe and gray matter atrophy, and cognitive decline in AD.

DOI10.3233/JAD-170519
Alternate JournalJ. Alzheimers Dis.
PubMed ID29171996
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Source URL: https://www.j-alz.com/content/cerebrospinal-fluid-c-c-motif-chemokine-ligand-2-correlates-brain-atrophy-and-cognitive