Title | Assessing Working Memory in Mild Cognitive Impairment with Serial Order Recall. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Emrani, S, Libon, DJ, Lamar, M, Price, CC, Jefferson, AL, Gifford, KA, Hohman, TJ, Nation, DA, Delano-Wood, L, Jak, A, Bangen, KJ, Bondi, MW, Brickman, AM, Manly, J, Swenson, R, Au, R |
Corporate Authors | Consortium for Clinical and Epidemiological Neuropsychological Data Analysis (CENDA) |
Journal | J Alzheimers Dis |
Volume | 61 |
Issue | 3 |
Pagination | 917-928 |
Date Published | 2018 |
ISSN | 1875-8908 |
Keywords | Aged, Aged, 80 and over, Cognitive Dysfunction, Executive Function, Female, Humans, Male, Memory Disorders, Memory, Short-Term, Mental Recall, Neuropsychological Tests, Regression Analysis, Serial Learning |
Abstract | BACKGROUND: Working memory (WM) is often assessed with serial order tests such as repeating digits backward. In prior dementia research using the Backward Digit Span Test (BDT), only aggregate test performance was examined. OBJECTIVE: The current research tallied primacy/recency effects, out-of-sequence transposition errors, perseverations, and omissions to assess WM deficits in patients with mild cognitive impairment (MCI). METHODS: Memory clinic patients (n = 66) were classified into three groups: single domain amnestic MCI (aMCI), combined mixed domain/dysexecutive MCI (mixed/dys MCI), and non-MCI where patients did not meet criteria for MCI. Serial order/WM ability was assessed by asking participants to repeat 7 trials of five digits backwards. Serial order position accuracy, transposition errors, perseverations, and omission errors were tallied. RESULTS: A 3 (group)×5 (serial position) repeated measures ANOVA yielded a significant group×trial interaction. Follow-up analyses found attenuation of the recency effect for mixed/dys MCI patients. Mixed/dys MCI patients scored lower than non-MCI patients for serial position 3 (p CONCLUSIONS: The attenuation of a recency effect using serial order parameters obtained from the BDT may provide a useful operational definition as well as additional diagnostic information regarding working memory deficits in MCI. |
DOI | 10.3233/JAD-170555 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 29254087 |
PubMed Central ID | PMC5901759 |
Grant List | P50 AG005142 / AG / NIA NIH HHS / United States K24 AG026431 / AG / NIA NIH HHS / United States R01 AG049810 / AG / NIA NIH HHS / United States IK2 CX000938 / CX / CSRD VA / United States K23 AG045966 / AG / NIA NIH HHS / United States K12 HD043483 / HD / NICHD NIH HHS / United States K01 AG049164 / AG / NIA NIH HHS / United States K24 AG046373 / AG / NIA NIH HHS / United States |