Title | Effects of Gender and Other Confounding Factors on Leptin Concentrations in Alzheimer's Disease: Evidence from the Combined Analysis of 27 Case-Control Studies. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Zhou, F, Chen, S |
Journal | J Alzheimers Dis |
Volume | 62 |
Issue | 1 |
Pagination | 477-486 |
Date Published | 2018 |
ISSN | 1875-8908 |
Abstract | Leptin, as a link between fat mass and the brain, has been reported to be associated with gender. The gender differences in leptin levels between Alzheimer's disease (AD) and healthy elderly controls are inconclusive so far. To quantitatively summarize the leptin data available from female and male patients with AD, we searched PubMed and EMBASE for articles published from inception to July 20, 2017. Data were extracted from 27 studies, consisting of 3,014 participants. The pooled results showed that the overall leptin levels were lower in AD (Hedges' g = -0.481; p = 0.002) than in controls, and the leptin levels in whole blood and serum were decreased with moderate and large effect sizes (g = -0.677, -0.839; respectively; both of p-values |
DOI | 10.3233/JAD-170983 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 29439354 |