| Title | Early Tau Burden Correlates with Higher Rate of Atrophy in Transentorhinal Cortex. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Xie, L, Das, SR, Wisse, LEM, Ittyerah, R, Yushkevich, PA, Wolk, DA |
| Corporate Authors | Alzheimer’s Disease Neuroimaging Initiative |
| Journal | J Alzheimers Dis |
| Volume | 62 |
| Issue | 1 |
| Pagination | 85-92 |
| Date Published | 2018 |
| ISSN | 1875-8908 |
| Abstract | Neurofibrillary tangle (NFT) pathology is linked to neurodegeneration in the medial temporal lobe (MTL). Using a tailored pipeline, we correlated atrophy rate, as measured from retrospective longitudinal MRI, with NFT burden, measured from 18F-AV-1451 PET, within MTL regions of earliest NFT pathology. In amyloid-β positive but not amyloid-β negative individuals, we found significant correlation between 18F-AV-1451 uptake and atrophy rate that was strongest in the transentorhinal cortex, the first region with NFT pathology. This supports the role of NFTs in driving neurodegeneration and the utility of 18F-AV-1451 PET and structural measurement of transentorhinal cortex in tracking early tau-mediated disease progression. |
| DOI | 10.3233/JAD-170945 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 29439350 |
| PubMed Central ID | PMC5880816 |
| Grant List | P30 AG010124 / AG / NIA NIH HHS / United States U01 AG024904 / AG / NIA NIH HHS / United States R01 EB017255 / EB / NIBIB NIH HHS / United States R01 AG037376 / AG / NIA NIH HHS / United States R01 AG040271 / AG / NIA NIH HHS / United States R01 AG056014 / AG / NIA NIH HHS / United States R01 AG055005 / AG / NIA NIH HHS / United States / / CIHR / Canada |
