| Title | Risk of Conversion to Dementia in a Mild Behavioral Impairment Group Compared to a Psychiatric Group and to a Mild Cognitive Impairment Group. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Taragano, FE, Allegri, RF, Heisecke, SL, Martelli, MI, Feldman, ML, Sánchez, V, García, VA, Tufro, G, Castro, DM, Leguizamón, PPerez, Guelar, V, Ruotolo, E, Zegarra, C, Dillon, C |
| Journal | J Alzheimers Dis |
| Volume | 62 |
| Issue | 1 |
| Pagination | 227-238 |
| Date Published | 2018 |
| ISSN | 1875-8908 |
| Abstract | BACKGROUND: There is insufficient available information on behavioral changes in the absence of cognitive impairment as factors increasing the risk of conversion to dementia. OBJECTIVE: To observe and analyze patients with mild behavioral impairment (MBI), mild cognitive impairment (MCI), and a psychiatry group (PG) to compare the risk of progression to dementia. METHODS: From 677 initially assessed ≥60-year-old patients, a series of 348 patients was studied for a five-year period until censoring or conversion to dementia: 96 with MBI, 87 with MCI, and 165 with general psychiatry disorders, including 4 subgroups: Anxiety, Depression, Psychosis and Others. All patients were assessed with clinical, psychiatric, neurological, neuropsychological, and neuroimaging studies. RESULTS: From 348 patients, 126 evolved to dementia (36.2%). Conversion was significantly higher in MBI (71.5%), followed by the MCI-MBI overlap (59.6%) and MCI (37.8%) groups, compared to PG (13.9%) (Log-rank p CONCLUSION: Conversion to dementia is significantly higher in patients with neuropsychiatric symptoms. The MBI concept generates a new milestone in the refining of diagnosis of neurodegenerative diseases and the possibility of creating neuropsychiatric profiles. Its earlier identification will allow new possibilities for therapeutic intervention. |
| DOI | 10.3233/JAD-170632 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 29439333 |
