Title | Impact of Total Knee Arthroplasty with General Anesthesia on Brain Networks: Cognitive Efficiency and Ventricular Volume Predict Functional Connectivity Decline in Older Adults. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Huang, H, Tanner, J, Parvataneni, H, Rice, M, Horgas, A, Ding, M, Price, C |
Journal | J Alzheimers Dis |
Volume | 62 |
Issue | 1 |
Pagination | 319-333 |
Date Published | 2018 |
ISSN | 1875-8908 |
Abstract | Using resting state functional magnetic resonance imaging (RS-fMRI), we explored: 1) pre- to post-operative changes in functional connectivity in default mode, salience, and central executive networks after total knee arthroplasty (TKA) with general anesthesia, and 2) the contribution of cognitive/brain reserve metrics these resting state functional declines. Individuals age 60 and older electing unilateral total knee arthroplasty (TKA; n = 48) and non-surgery peers with osteoarthritis (n = 45) completed baseline cognitive testing and baseline and post-surgery (post-baseline, 48-h post-surgery) brain MRI. We acquired cognitive and brain estimates for premorbid (vocabulary, reading, education, intracranial volume) and current (working memory, processing speed, declarative memory, ventricular volume) reserve. Functional network analyses corrected for pain severity and pain medication. The surgery group declined in every functional network of interest (p |
DOI | 10.3233/JAD-170496 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 29439328 |
PubMed Central ID | PMC5827939 |
Grant List | F32 AG021363 / AG / NIA NIH HHS / United States R01 NR014181 / NR / NINR NIH HHS / United States UL1 TR001427 / TR / NCATS NIH HHS / United States KL2 TR001429 / TR / NCATS NIH HHS / United States TL1 TR001428 / TR / NCATS NIH HHS / United States |