Title | Pramlintide: The Effects of a Single Drug Injection on Blood Phosphatidylcholine Profile for Alzheimer's Disease. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Tao, Q, Zhu, H, Chen, X, Stern, RA, Kowall, N, Au, R, Blusztajn, JKrzysztof, Qiu, WQiao |
Corporate Authors | Alzheimer’s Disease Metabolomics Consortium |
Journal | J Alzheimers Dis |
Volume | 62 |
Issue | 2 |
Pagination | 597-609 |
Date Published | 2018 |
ISSN | 1875-8908 |
Keywords | Aged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Peptides, Biomarkers, Cognitive Dysfunction, Female, Humans, Islet Amyloid Polypeptide, Logistic Models, Male, Middle Aged, Phosphatidylcholines, ROC Curve, tau Proteins |
Abstract | Studies suggest that a single injection of pramlintide, an amylin analog, induces changes in Alzheimer's disease (AD) biomarkers in the blood of AD mouse models and AD patients. The aim of this study was to examine whether a pramlintide challenge combined with a phosphatidylcholine (PC) profile diagnoses of AD and mild cognitive impairment (MCI) better than PC alone. Non-diabetic subjects with cognitive status were administered a single subcutaneous injection of 60 mcg of pramlintide under fasting condition. A total of 71 PCs, amyloid-β peptide (Aβ), and total tau (t-tau) in plasma at different time points were measured and treated as individual variables. A single injection of pramlintide altered the levels of 7 PCs in the blood, while a pramlintide injection plus food modulated the levels of 10 PCs in the blood (p |
DOI | 10.3233/JAD-170948 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 29480193 |
PubMed Central ID | PMC5956916 |
Grant List | R01 AG046171 / AG / NIA NIH HHS / United States U01 AG024904 / AG / NIA NIH HHS / United States U19 AG024904 / AG / NIA NIH HHS / United States R01 AG049899 / AG / NIA NIH HHS / United States R01 AG045031 / AG / NIA NIH HHS / United States R21 AG045757 / AG / NIA NIH HHS / United States R56 AG057768 / AG / NIA NIH HHS / United States RF1 AG051550 / AG / NIA NIH HHS / United States |