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Home > Deep Brain Stimulation of Frontal Lobe Networks to Treat Alzheimer's Disease.

TitleDeep Brain Stimulation of Frontal Lobe Networks to Treat Alzheimer's Disease.
Publication TypeJournal Article
Year of Publication2018
AuthorsScharre, DW, Weichart, E, Nielson, D, Zhang, J, Agrawal, P, Sederberg, PB, Knopp, MV, Rezai, AR
Corporate AuthorsAlzheimer’s Disease Neuroimaging Initiative
JournalJ Alzheimers Dis
Volume62
Issue2
Pagination621-633
Date Published2018
ISSN1875-8908
KeywordsAged, Alzheimer Disease, Deep Brain Stimulation, Female, Frontal Lobe, Humans, Male, Middle Aged, Ohio, Pilot Projects, Positron-Emission Tomography, Prospective Studies
Abstract

The study objective was to evaluate the safety and efficacy of deep brain stimulation (DBS) at the ventral capsule/ventral striatum (VC/VS) region to specifically modulate frontal lobe behavioral and cognitive networks as a novel treatment approach for Alzheimer's disease (AD) patients. This is a non-randomized phase I prospective open label interventional trial of three subjects with matched comparison groups. AD participants given DBS for at least 18 months at the VC/VS target were compared on the Clinical Dementia Rating-Sum of Boxes (CDR-SB), our primary outcome clinical measure, to matched groups without DBS from the AD Neuroimaging Initiative (ADNI) cohort. Serial 2-Deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography (PET) images of AD participants were also compared longitudinally over time. Three AD DBS participants were matched to subjects from the ADNI cohort. All participants tolerated DBS well without significant adverse events. All three AD DBS participants had less performance decline and two of them meaningfully less decline over time on our primary outcome measure, CDR-SB, relative to matched comparison groups from the ADNI using score trajectory slopes. Minimal changes or increased metabolism on FDG-PET were seen in frontal cortical regions after chronic DBS at the VC/VS target. The first use of DBS in AD at a frontal lobe behavior regulation target (VC/VS) was well-tolerated and revealed less performance decline in CDR-SB. Frontal network modulation to improve executive and behavioral deficits should be furthered studied in AD.

DOI10.3233/JAD-170082
Alternate JournalJ. Alzheimers Dis.
PubMed ID29400666
Grant ListR01 EB006136 / EB / NIBIB NIH HHS / United States
U01 AG024904 / AG / NIA NIH HHS / United States
/ / CIHR / Canada
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Source URL: https://www.j-alz.com/content/deep-brain-stimulation-frontal-lobe-networks-treat-alzheimers-disease