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Home > Understanding Epigenetics in the Neurodegeneration of Alzheimer's Disease: SAMP8 Mouse Model.

TitleUnderstanding Epigenetics in the Neurodegeneration of Alzheimer's Disease: SAMP8 Mouse Model.
Publication TypeJournal Article
Year of Publication2018
AuthorsGriñán-Ferré, C, Corpas, R, Puigoriol-Illamola, D, Palomera-Ávalos, V, Sanfeliu, C, Pallas, M
JournalJ Alzheimers Dis
Volume62
Issue3
Pagination943-963
Date Published2018
ISSN1875-8908
Abstract

Epigenetics is emerging as the missing link among genetic inheritance, environmental influences, and body and brain health status. In the brain, specific changes in nucleic acids or their associated proteins in neurons and glial cells might imprint differential patterns of gene activation that will favor either cognitive enhancement or cognitive loss for more than one generation. Furthermore, derangement of age-related epigenetic signaling is appearing as a significant risk factor for illnesses of aging, including neurodegeneration and Alzheimer's disease (AD). In addition, better knowledge of epigenetic mechanisms might provide hints and clues in the triggering and progression of AD. Intense research in experimental models suggests that molecular interventions for modulating epigenetic mechanisms might have therapeutic applications to promote cognitive maintenance through an advanced age. The SAMP8 mouse is a senescence model with AD traits in which the study of epigenetic alterations may unveil epigenetic therapies against the AD.

DOI10.3233/JAD-170664
Alternate JournalJ. Alzheimers Dis.
PubMed ID29562529
PubMed Central IDPMC5870033
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Source URL: https://www.j-alz.com/content/understanding-epigenetics-neurodegeneration-alzheimers-disease-samp8-mouse-model