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Home > Post Traumatic Stress Disorder Heralding the Onset of Semantic Frontotemporal Dementia.

TitlePost Traumatic Stress Disorder Heralding the Onset of Semantic Frontotemporal Dementia.
Publication TypeJournal Article
Year of Publication2018
AuthorsBonanni, L, Franciotti, R, Martinotti, G, Vellante, F, Flacco, MElena, Di Giannantonio, M, Thomas, A, Onofrj, M
JournalJ Alzheimers Dis
Volume63
Issue1
Pagination203-215
Date Published2018
ISSN1875-8908
Abstract

BACKGROUND: Post traumatic stress disorder (PTSD) is associated with cognitive decline. The dementia type following PTSD is unclear.

OBJECTIVE: To assess whether PTSD is associated with a specific dementia.

METHODS: Prospective study: 46 PTSD patients (DSM-IV-TR) were followed for 6-10 years with clinical, neuropsychological, imaging evaluations for possible development of dementia.Retrospective study:849 dementia patients followed during 1999-2014 (509 Alzheimer's disease, AD; 207 dementia with Lewy bodies, DLB; 90 vascular dementia, VaD; 43 frontotemporal dementia, FTD) and 287 patients with any neurological condition (including patients with/without dementia) were evaluated for the presence of PTSD in their history.

RESULTS: Prospective study: 8 patients developed dementia; 1 AD, 1 DLB, 6 semantic FTD (13.0% of the PTSD population). Retrospective study: 38 patients (4.5%) had a history of PTSD; 3.5% of AD, 4.3% of DLB, 14.0% of FTD, 5.6% of VaD. The percentage was higher in FTD than in AD or DLB (χ2 = 10, p = 0.001, and χ2 = 6, p = 0.02). At difference with AD, DLB, or VaD, FTD incidence among dementia patients with PTSD history (38 patients) was higher than in the dementia population overall (16% versus 5%, χ2 = 8, p = 0.005). The impact of possible demographical/clinical confounders (age, gender, MMSE) was excluded by Poisson regression. PTSD prevalence in the comparative group without dementia matched the prevalence in the Italian general population (1.1%). PTSD prevalence in the demented comparative group matched the prevalence in our dementia retrospective cohort, 3.7%).

DISCUSSION: PTSD was associated with the development of semantic FTD.

DOI10.3233/JAD-171134
Alternate JournalJ. Alzheimers Dis.
PubMed ID29614666
PubMed Central IDPMC5900559
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Source URL: https://www.j-alz.com/content/post-traumatic-stress-disorder-heralding-onset-semantic-frontotemporal-dementia