Journal of Alzheimer's Disease
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Home > Serum Copper is not Altered in Frontotemporal Lobar Degeneration.

TitleSerum Copper is not Altered in Frontotemporal Lobar Degeneration.
Publication TypeJournal Article
Year of Publication2018
AuthorsSquitti, R, Fostinelli, S, Siotto, M, Ferrari, C, Binetti, G, Benussi, L, Rongioletti, M, Ghidoni, R
JournalJ Alzheimers Dis
Volume63
Issue4
Pagination1427-1432
Date Published2018
ISSN1875-8908
Abstract

Meta-analyses show copper dyshomeostasis in Alzheimer's disease. However, a study evaluating copper changes in other neurodegenerative forms of dementia has not yet been performed. In this study, we assessed copper, ceruloplasmin, copper not bound to ceruloplasmin, and copper to ceruloplasmin ratio in 85 patients affected by frontotemporal lobar degeneration (FTLD) and 55 healthy controls. Data were analyzed through multivariate ANOVA models taking into account age and sex as covariates and the stratification for FTLD variants, after calculating power analysis to ensure the reliability of the conclusions drawn. The study revealed no difference between the groups.

DOI10.3233/JAD-171074
Alternate JournalJ. Alzheimers Dis.
PubMed ID29843237
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Source URL: https://www.j-alz.com/content/serum-copper-not-altered-frontotemporal-lobar-degeneration