| Title | Meta-Analysis of the Association between Variants in ABCA7 and Alzheimer's Disease. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Ma, F-C, Wang, H-F, Cao, X-P, Tan, C-C, Tan, L, Yu, J-T |
| Journal | J Alzheimers Dis |
| Volume | 63 |
| Issue | 4 |
| Pagination | 1261-1267 |
| Date Published | 2018 |
| ISSN | 1875-8908 |
| Abstract | The ATP-binding cassette transporter A7 (ABCA7) was identified as a known risk factor for Alzheimer's disease (AD). However, the relation between ABCA7 and AD was still inconsistent across these studies. Here, our meta-analysis aimed at confirming the association of ABCA7 with AD. Finally, 16 case-control studies (63747 versus 85833) were retrieved from PubMed and other databases. Three common loci were confirmed to increase the risk of AD (rs3764650: OR = 1.20, 95% CI = 1.16-1.24; rs3752246: OR = 1.13,95% CI = 1.08-1.19; rs4147929: OR = 1.17, 95% CI = 1.10-1.24), but the associations varied among the different races. Furthermore, ABCA7 loss-of-function (LOF) mutations conferred a higher risk for AD than did the above variants (LOF: OR = 1.78, 95% = 1.43-2.22). In conclusion, ABCA7 genetic variants, especially the LOF mutations, were significantly associated with the risk of AD. |
| DOI | 10.3233/JAD-180107 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 29782324 |
