Journal of Alzheimer's Disease
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Home > Higher Blood Vitamin C Levels are Associated with Reduction of Apolipoprotein E E4-related Risks of Cognitive Decline in Women: The Nakajima Study.

TitleHigher Blood Vitamin C Levels are Associated with Reduction of Apolipoprotein E E4-related Risks of Cognitive Decline in Women: The Nakajima Study.
Publication TypeJournal Article
Year of Publication2018
AuthorsNoguchi-Shinohara, M, Abe, C, Yuki-Nozaki, S, Dohmoto, C, Mori, A, Hayashi, K, Shibata, S, Ikeda, Y, Sakai, K, Iwasa, K, Yokogawa, M, Ishimiya, M, Nakamura, H, Yokoji, H, Komai, K, Nakamura, H, Yamada, M
JournalJ Alzheimers Dis
Volume63
Issue4
Pagination1289-1297
Date Published2018
ISSN1875-8908
Abstract

BACKGROUND: Antioxidants like vitamins C and E may minimize the risk for Alzheimer's disease.

OBJECTIVE: We examined whether vitamins C and E modify the apolipoprotein E (APOE) E4-related risks for developing cognitive decline.

METHODS: We conducted a population-based prospective study including Japanese residents aged 65 years from Nakajima, Japan. The participants received an evaluation of cognitive function and underwent blood tests including tests for vitamins C and E levels and APOE phenotypes. The APOE E4-by-gender-by-vitamin C or E interactions on developing cognitive decline were analyzed.

RESULTS: Of 606 participants with normal cognitive function determined using a baseline survey (2007-2008), 349 completed the follow up survey between 2014 and 2016. In women with APOE E4, significantly reduced risk for cognitive decline was observed for the highest blood vitamin C concentration tertile [multivariate OR 0.10 (95% CI 0.01-0.93)] compared with the lowest tertile. In men without APOE E4, significantly reduced risk for cognitive decline was observed for the highest blood vitamin E concentration tertile [multivariate OR 0.19 (0.05-0.74)] as compared with the lowest tertile.

CONCLUSION: Our results demonstrate significant beneficial effects of vitamins C and E in reducing the risk of cognitive decline in women with APOE E4 and men without APOE E4, respectively.

DOI10.3233/JAD-170971
Alternate JournalJ. Alzheimers Dis.
PubMed ID29758939
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Source URL: https://www.j-alz.com/content/higher-blood-vitamin-c-levels-are-associated-reduction-apolipoprotein-e-e4-related-risks