Title | Higher Blood Vitamin C Levels are Associated with Reduction of Apolipoprotein E E4-related Risks of Cognitive Decline in Women: The Nakajima Study. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Noguchi-Shinohara, M, Abe, C, Yuki-Nozaki, S, Dohmoto, C, Mori, A, Hayashi, K, Shibata, S, Ikeda, Y, Sakai, K, Iwasa, K, Yokogawa, M, Ishimiya, M, Nakamura, H, Yokoji, H, Komai, K, Nakamura, H, Yamada, M |
Journal | J Alzheimers Dis |
Volume | 63 |
Issue | 4 |
Pagination | 1289-1297 |
Date Published | 2018 |
ISSN | 1875-8908 |
Abstract | BACKGROUND: Antioxidants like vitamins C and E may minimize the risk for Alzheimer's disease. OBJECTIVE: We examined whether vitamins C and E modify the apolipoprotein E (APOE) E4-related risks for developing cognitive decline. METHODS: We conducted a population-based prospective study including Japanese residents aged 65 years from Nakajima, Japan. The participants received an evaluation of cognitive function and underwent blood tests including tests for vitamins C and E levels and APOE phenotypes. The APOE E4-by-gender-by-vitamin C or E interactions on developing cognitive decline were analyzed. RESULTS: Of 606 participants with normal cognitive function determined using a baseline survey (2007-2008), 349 completed the follow up survey between 2014 and 2016. In women with APOE E4, significantly reduced risk for cognitive decline was observed for the highest blood vitamin C concentration tertile [multivariate OR 0.10 (95% CI 0.01-0.93)] compared with the lowest tertile. In men without APOE E4, significantly reduced risk for cognitive decline was observed for the highest blood vitamin E concentration tertile [multivariate OR 0.19 (0.05-0.74)] as compared with the lowest tertile. CONCLUSION: Our results demonstrate significant beneficial effects of vitamins C and E in reducing the risk of cognitive decline in women with APOE E4 and men without APOE E4, respectively. |
DOI | 10.3233/JAD-170971 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 29758939 |