Title | Relationships between Cognition and Activities of Daily Living in Alzheimer's Disease During a 5-Year Follow-Up: ALSOVA Study. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Saari, T, Hallikainen, I, Hänninen, T, Räty, H, Koivisto, A |
Journal | J Alzheimers Dis |
Volume | 64 |
Issue | 1 |
Pagination | 269-279 |
Date Published | 2018 |
ISSN | 1875-8908 |
Abstract | BACKGROUND: Impaired cognition and activities of daily living (ADL) are core symptoms of Alzheimer's disease (AD), but their relationship is unclear. OBJECTIVES: To explore relationships between cognitive domains and functional ability during 5-year follow-up in persons with AD. METHODS: We analyzed ALSOVA study data from 236 individuals with very mild or mild AD at baseline. The CERAD Neuropsychological Battery (CERAD-NB) was used as a cognitive measure and Alzheimer's Disease Cooperative Study ADL (ADCS-ADL) as a functional measure, analyzing the IADL and BADL sub-scores separately. Annual regression models and linear mixed-effect models (LMMs) covering a 5-year follow-up period were used. RESULTS: Annually, the CERAD-NB total and especially Verbal Fluency, Clock Drawing, and Constructional Praxis were associated with the total ADCS-ADL and IADL scores increasingly yet modestly, and to a lesser extent the BADL score. In the LMMs, the same measures and MMSE were associated with ADL. CONCLUSION: Measures of executive function and visuoconstructive skills appear to be associated with caregiver-interview based ADL measure during the progression of AD. |
DOI | 10.3233/JAD-171059 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 29889073 |