Title | Hippocampal Subfield Volumetry: Differential Pattern of Atrophy in Different Forms of Genetic Frontotemporal Dementia. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Bocchetta, M, Iglesias, JEugenio, Scelsi, MA, Cash, DM, M Cardoso, J, Modat, M, Altmann, A, Ourselin, S, Warren, JD, Rohrer, JD |
Journal | J Alzheimers Dis |
Volume | 64 |
Issue | 2 |
Pagination | 497-504 |
Date Published | 2018 |
ISSN | 1875-8908 |
Abstract | BACKGROUND: Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder, with a strong genetic component. Previous research has shown that medial temporal lobe atrophy is a common feature of FTD. However, no study has so far investigated the differential vulnerability of the hippocampal subfields in FTD. OBJECTIVES: We aimed to investigate hippocampal subfield volumes in genetic FTD. METHODS: We in6/2/2018vestigated hippocampal subfield volumes in a cohort of 75 patients with genetic FTD (age: mean (standard deviation) 59.3 (7.7) years; disease duration: 5.1 (3.4) years; 29 with MAPT, 28 with C9orf72, and 18 with GRN mutations) compared with 97 age-matched controls (age: 62.1 (11.1) years). We performed a segmentation of their volumetric T1-weighted MRI scans to extract hippocampal subfields volumes. Left and right volumes were summed and corrected for total intracranial volumes. RESULTS: All three groups had smaller hippocampi than controls. The MAPT group had the most atrophic hippocampi, with the subfields showing the largest difference from controls being CA1-4 (24-27%, p CONCLUSIONS: The hippocampus was affected in all mutation types but a different pattern of subfield involvement was found in the three genetic groups, consistent with differential cortical-subcortical network vulnerability. |
DOI | 10.3233/JAD-180195 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 29889066 |
PubMed Central ID | PMC6027942 |
Grant List | / / Wellcome Trust / United Kingdom MR/J01107X/1 / / Medical Research Council / United Kingdom MR/L016311/1 / / Medical Research Council / United Kingdom |