Title | Clinical Subtypes of Dementia with Lewy Bodies Based on the Initial Clinical Presentation. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Morenas-Rodriguez, E, Sala, I, Subirana, A, Pascual-Goñi, E, Sánchez-Saudinós, MBelén, Alcolea, D, Illán-Gala, I, Carmona-Iragui, M, Ribosa-Nogué, R, Camacho, V, Blesa, R, Fortea, J, Lleo, A |
Journal | J Alzheimers Dis |
Volume | 64 |
Issue | 2 |
Pagination | 505-513 |
Date Published | 2018 |
ISSN | 1875-8908 |
Abstract | BACKGROUND: Dementia with Lewy bodies (DLB) is a heterogeneous disease in which clinical presentation, symptoms, and evolution widely varies between patients. OBJECTIVE: To investigate the existence of clinical subtypes in DLB based on the initial clinical presentation. METHODS: 81 patients with a clinical diagnosis of probable DLB were consecutively included. All patients underwent a neurological evaluation including a structured questionnaire about neuropsychiatric symptoms and sleep, an assessment of motor impairment (Unified Parkinson Disease Rating Scale subscale III), and a formal neuropsychological evaluation. Onset of core symptoms (hallucinations, parkinsonism, and fluctuations) and dementia were systematically reviewed from medical records. We applied a K-means clustering method based on the initial clinical presentation. RESULTS: Cluster analysis yielded three different groups. Patients in cluster I (cognitive-predominant, n = 46) presented more frequently with cognitive symptoms (95.7%, n = 44, p CONCLUSIONS: Three clinical subtypes of DLB can be defined when considering the differential initial presentations. The proposed subtypes have distinct clinical profiles and progression patterns. |
DOI | 10.3233/JAD-180167 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 29889064 |