| Title | Cerebrospinal Fluid Levels of Angiotensin-Converting Enzyme Are Associated with Amyloid-β42 Burden in Alzheimer's Disease. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Rocha, NP, Toledo, A, Corgosinho, LTS, de Souza, LC, Guimarães, HC, Resende, EPF, Braz, NFT, Gomes, KB, Silva, ACSimoes E, Caramelli, P, Teixeira, AL |
| Journal | J Alzheimers Dis |
| Volume | 64 |
| Issue | 4 |
| Pagination | 1085-1090 |
| Date Published | 2018 |
| ISSN | 1875-8908 |
| Abstract | This study was designed to determine whether the levels of renin-angiotensin system (RAS) components are associated with Alzheimer's disease (AD) pathology. Cerebrospinal fluid levels of Angiotensin (Ang) II, Ang-(1-7), angiotensin-converting enzyme (ACE), ACE2, Amyloid-β (Aβ)40, Aβ42, total tau (hTau), and phospho-tau (pTau) were measured in 18 patients with AD and 10 controls. Patients with AD presented decreased levels of ACE when compared with controls. We found a significant positive correlation between ACE and Aβ42 levels among patients. Our results strengthen the hypothesis that ACE is associated with Aβ pathology in AD. |
| DOI | 10.3233/JAD-180282 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 30040721 |
