| Title | Cerebral Amyloid Angiopathy and Cerebral Amyloid Angiopathy-Related Inflammation: Comparison of Hemorrhagic and DWI MRI Features. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Renard, D, Tatu, L, Collombier, L, Wacongne, A, Ayrignac, X, Charif, M, Boukriche, Y, Chiper, L, Fourcade, G, Azakri, S, Gaillard, N, Mercier, E, Lehmann, S, Thouvenot, E |
| Journal | J Alzheimers Dis |
| Volume | 64 |
| Issue | 4 |
| Pagination | 1113-1121 |
| Date Published | 2018 |
| ISSN | 1875-8908 |
| Abstract | BACKGROUND: Cerebral amyloid angiopathy (CAA) can be associated with primary vasculitis of small/medium-sized leptomeningeal and cortical arteries, called CAA-related inflammation (CAA-ri). OBJECTIVE: To compare hemorrhagic and diffusion-weighted imaging (DWI) MRI features in CAA and CAA-ri. METHODS: We prospectively scored in a consecutive CAA and CAA-ri cohort: presence/number of chronic intracerebral hemorrhage (ICH), cerebral microbleeds (CMB), and cortical superficial siderosis (CSS) on initial T2*-weighted imaging, and DWI lesions on both initial and follow-up imaging. In a subgroup, ApoE, CSF, and 18F-florbetaben-positron emission tomography (FBB-PET) were also analyzed. RESULTS: In CAA-ri, CMB presence was more frequent (100% versus 40%, p CONCLUSION: Compared to CAA, CAA-ri was associated with higher CMB numbers, more frequent ApoE4 carriers and homozygotes, lower CSF Aβ42 levels, and more severe amyloid load on FBB-PET. |
| DOI | 10.3233/JAD-180269 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 30010128 |
