| Title | Preoperative Phosphorylated Tau Concentration in the Cerebrospinal Fluid Can Predict Cognitive Function Three Years after Shunt Surgery in Patients with Idiopathic Normal Pressure Hydrocephalus. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Nakajima, M, Miyajima, M, Ogino, I, Akiba, C, Kawamura, K, Kamohara, C, Fusegi, K, Harada, Y, Hara, T, Sugano, H, Tange, Y, Karagiozov, K, Kasuga, K, Ikeuchi, T, Tokuda, T, Arai, H |
| Journal | J Alzheimers Dis |
| Volume | 66 |
| Issue | 1 |
| Pagination | 319-331 |
| Date Published | 2018 |
| ISSN | 1875-8908 |
| Abstract | BACKGROUND: Idiopathic normal pressure hydrocephalus (iNPH) is commonly treated by cerebrospinal fluid (CSF) shunting. However, the long-term efficacy of shunt intervention in the presence of comorbid Alzheimer's disease (AD) pathology is debated. OBJECTIVE: To identify AD-associated CSF biomarkers predictive of shunting surgery outcomes in patients with iNPH. METHODS: Preoperative levels of total and phosphorylated Tau (p-Tau) were measured in 40 patients with iNPH divided into low ( RESULTS: Cognitive function improved early in the low p-Tau group and was maintained thereafter (p = 0.005). In contrast, the high p-Tau group showed a gradual decline to baseline levels by the third postoperative year (p = 0.040). Although the p-Tau concentration did not correlate with the preoperative MMSE score, a negative correlation appeared and strengthened during follow-up (R2 = 0.352, p CONCLUSIONS: Preoperative CSF p-Tau concentration predicted some aspects of cognitive function after shunt intervention in patients with iNPH. The therapeutic effects of shunt treatment were shorter-lasting in patients with coexisting AD pathology. |
| DOI | 10.3233/JAD-180557 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 30248058 |
| PubMed Central ID | PMC6218133 |
