Journal of Alzheimer's Disease
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Home > Preoperative Phosphorylated Tau Concentration in the Cerebrospinal Fluid Can Predict Cognitive Function Three Years after Shunt Surgery in Patients with Idiopathic Normal Pressure Hydrocephalus.

TitlePreoperative Phosphorylated Tau Concentration in the Cerebrospinal Fluid Can Predict Cognitive Function Three Years after Shunt Surgery in Patients with Idiopathic Normal Pressure Hydrocephalus.
Publication TypeJournal Article
Year of Publication2018
AuthorsNakajima, M, Miyajima, M, Ogino, I, Akiba, C, Kawamura, K, Kamohara, C, Fusegi, K, Harada, Y, Hara, T, Sugano, H, Tange, Y, Karagiozov, K, Kasuga, K, Ikeuchi, T, Tokuda, T, Arai, H
JournalJ Alzheimers Dis
Volume66
Issue1
Pagination319-331
Date Published2018
ISSN1875-8908
Abstract

BACKGROUND: Idiopathic normal pressure hydrocephalus (iNPH) is commonly treated by cerebrospinal fluid (CSF) shunting. However, the long-term efficacy of shunt intervention in the presence of comorbid Alzheimer's disease (AD) pathology is debated.

OBJECTIVE: To identify AD-associated CSF biomarkers predictive of shunting surgery outcomes in patients with iNPH.

METHODS: Preoperative levels of total and phosphorylated Tau (p-Tau) were measured in 40 patients with iNPH divided into low (

RESULTS: Cognitive function improved early in the low p-Tau group and was maintained thereafter (p = 0.005). In contrast, the high p-Tau group showed a gradual decline to baseline levels by the third postoperative year (p = 0.040). Although the p-Tau concentration did not correlate with the preoperative MMSE score, a negative correlation appeared and strengthened during follow-up (R2 = 0.352, p 

CONCLUSIONS: Preoperative CSF p-Tau concentration predicted some aspects of cognitive function after shunt intervention in patients with iNPH. The therapeutic effects of shunt treatment were shorter-lasting in patients with coexisting AD pathology.

DOI10.3233/JAD-180557
Alternate JournalJ. Alzheimers Dis.
PubMed ID30248058
PubMed Central IDPMC6218133
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Source URL: https://www.j-alz.com/content/preoperative-phosphorylated-tau-concentration-cerebrospinal-fluid-can-predict-cognitive