Title | Age-Dependent Decrease of Mitochondrial Complex II Activity in a Familial Mouse Model for Alzheimer's Disease. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Emmerzaal, TL, Rodenburg, RJ, Tanila, H, Verweij, V, Kiliaan, AJ, Kozicz, T |
Journal | J Alzheimers Dis |
Volume | 66 |
Issue | 1 |
Pagination | 75-82 |
Date Published | 2018 |
ISSN | 1875-8908 |
Abstract | Alzheimer's disease (AD) is a severe neurodegenerative disorder for which the exact etiology is largely unknown. An increasingly recognized and investigated notion is the pathogenic role of mitochondrial dysfunction in AD. We assessed mitochondrial oxidative-phosphorylation (OXPHOS) enzyme activities in the APPswe/PS1ΔE9 mouse model from 4.5 to 14 months of age. We show an age-dependent decrease in mitochondrial complex-II activity starting at 9 months in APP/PS1 mice. Other enzymes of the OXPHOS do not show any alterations. Since amyloid-β (Aβ) plaques are already present from 4 months of age, mitochondrial dysfunction likely occurs downstream of Aβ pathology in this mouse model. |
DOI | 10.3233/JAD-180337 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 30248054 |