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Home > High-Density Lipoprotein Subclasses and Mild Cognitive Impairment: Study of Outcome and aPolipoproteins in Dementia (STOP-Dementia)1.

TitleHigh-Density Lipoprotein Subclasses and Mild Cognitive Impairment: Study of Outcome and aPolipoproteins in Dementia (STOP-Dementia)1.
Publication TypeJournal Article
Year of Publication2018
AuthorsOhtani, R, Nirengi, S, Nakamura, M, Murase, N, Sainouchi, M, Kuwata, Y, Takata, M, Masuda, Y, Kotani, K, Sakane, N
JournalJ Alzheimers Dis
Volume66
Issue1
Pagination289-296
Date Published2018
ISSN1875-8908
Abstract

BACKGROUND: High-density lipoprotein (HDL) containing apolipoprotein A-I is associated with the pathogenesis of Alzheimer's disease (AD). HDL particle size is modified in the presence of pathological conditions, while the significance of the HDL particle size remains controversial.

OBJECTIVE: The aim of this study was to investigate the HDL lipoprotein subclasses in mild cognitive impairment (MCI) and AD.

METHODS: This cross-sectional study included 20 AD patients, 17 MCI patients, and 17 age-matched controls without cognitive impairment, selected from the database of the Study of Outcome and aPolipoproteins in Dementia (STOP-Dementia) registry. The diagnoses of AD and MCI were performed by expert neurologists according to the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition criteria. Serum HDL subclasses were measured by electrophoretic separation of lipoproteins using the Lipoprint System. The neutrophil-lymphocyte ratio (NLR), a marker of inflammation, was calculated by dividing the neutrophil count by the lymphocyte count.

RESULTS: Small-sized HDL particle levels in the MCI group were significantly higher than in the control group, although there was no difference in serum HDL-cholesterol levels between MCI and control groups. NLR in the MCI group was higher than in the control group, but this difference was non-significant (pā€Š=ā€Š0.09). There was no difference in HDL subclasses or NLR between the AD and control groups.

CONCLUSION: These findings suggest that HDL subclasses might be associated with the development of MCI.

DOI10.3233/JAD-180135
Alternate JournalJ. Alzheimers Dis.
PubMed ID30248050
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