Title | Patterns of Neuropsychological Dysfunction and Cortical Volume Changes in Logopenic Aphasia. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Owens, TE, Machulda, MM, Duffy, JR, Strand, EA, Clark, HM, Boland, S, Martin, PR, Lowe, VJ, Jack, CR, Whitwell, JL, Josephs, KA |
Journal | J Alzheimers Dis |
Volume | 66 |
Issue | 3 |
Pagination | 1015-1025 |
Date Published | 2018 |
ISSN | 1875-8908 |
Abstract | BACKGROUND: Neuropsychological assessment can add essential information to the characterization of individuals presenting with the logopenic variant of primary progressive aphasia (lvPPA). OBJECTIVE: This study examined the neuropsychological characteristics of lvPPA patients. We also examined differences in regional and whole brain atrophy based on neuropsychological profiles. METHODS: We conducted a hierarchical cluster analysis on memory, executive functioning, and visuospatial neuropsychological test data for 56 individuals with lvPPA. We then compared resultant clusters to left middle temporal, inferior parietal, and superior parietal regions-of-interest using multivariate analysis of covariance. We also performed voxel-level analyses. RESULTS: We identified three clusters characterized as lvPPA with no neurocognitive impairment (n = 5), lvPPA with mild neurocognitive deficits (n = 23), and lvPPA with marked cognitive deficits (n = 28). WAB-AQ was associated with left middle temporal volume. Superior parietal volumes were smaller for the lvPPA group with marked cognitive symptoms compared to the less severe groups. Voxel-level analyses showed greater atrophy in temporal, parietal, lateral occipital, and frontal regions, left worse than right. Age, disease duration, gender, WAB-AQ, and PiB-PET did not account for differences between groups. CONCLUSIONS: LvPPA patients without cognitive deficits in other domains were relatively uncommon while 50% of our sample exhibited pronounced neurocognitive deficits outside the language domain. Pronounced cognitive deficits in lvPPA are associated with widespread atrophy, left worse than right. Our study underscores the importance of examining neuropsychological function in addition to language in patients with lvPPA. |
DOI | 10.3233/JAD-171175 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 30372673 |
PubMed Central ID | PMC6322407 |
Grant List | R01 AG041851 / AG / NIA NIH HHS / United States U01 AG032438 / AG / NIA NIH HHS / United States P50 AG016574 / AG / NIA NIH HHS / United States U01 HL096917 / HL / NHLBI NIH HHS / United States R01 AG049810 / AG / NIA NIH HHS / United States U01 AG024904 / AG / NIA NIH HHS / United States R01 AG011378 / AG / NIA NIH HHS / United States R01 DC012519 / DC / NIDCD NIH HHS / United States R01 AG037551 / AG / NIA NIH HHS / United States R01 NS089757 / NS / NINDS NIH HHS / United States R01 DC010367 / DC / NIDCD NIH HHS / United States R01 AG037491 / AG / NIA NIH HHS / United States R21 NS094684 / NS / NINDS NIH HHS / United States U01 AG006786 / AG / NIA NIH HHS / United States R01 AG050603 / AG / NIA NIH HHS / United States |