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Home > Utility of Amyloid PET Scans in the Evaluation of Patients Presenting with Diverse Cognitive Complaints.

TitleUtility of Amyloid PET Scans in the Evaluation of Patients Presenting with Diverse Cognitive Complaints.
Publication TypeJournal Article
Year of Publication2018
AuthorsShea, Y-F, Barker, W, Greig-Gusto, MT, Loewenstein, DA, DeKosky, ST, Duara, R
JournalJ Alzheimers Dis
Volume66
Issue4
Pagination1599-1608
Date Published2018
ISSN1875-8908
Abstract

BACKGROUND: The impact of amyloid positron emission tomography (Aβ-PET) in a "real-world" memory disorders clinic remains poorly studied.

OBJECTIVE: We studied the impact of Aβ-PET in diagnosis and management in the memory clinic and factors making the most impact in diagnosis and management.

METHODS: We studied 102 patients who had presented at a memory disorders clinic (the Wien Center for Alzheimer's Disease and Memory Disorders, Miami Beach, FL) and had a diagnostic work-up for cognitive complaints, including Aβ-PET scans.

RESULTS: Following Aβ-PET, changes were made in diagnosis (37.3%), in specific treatments for Alzheimer's disease (26.5%) and in psychiatric treatments (25.5%). The agreement between diagnosis pre-Aβ-PET versus post-Aβ-PET diagnosis was only fair, with a Cohen's kappa of 0.23 (95% CI 0-0.42). Patients with MRI findings suggestive of AD (medial temporal and/or parietal atrophy) were more frequently amyloid positive than amyloid negative (66.2% versus 33.8%, p = 0.04). Among patients with atypical clinical features for AD, but with MRI findings suggestive of AD, an amyloid negative PET scan had a greater impact than an amyloid positive PET scan on diagnosis (84.2% versus 17.1%, p 

CONCLUSIONS: We conclude that MRI features suggestive of AD predict a positive amyloid PET scan. However, among those with MRI features suggestive of AD but with atypical clinical features of AD, the clinical impact on diagnosis and management is greater for an amyloid negative than an amyloid positive Aβ-PET scans.

DOI10.3233/JAD-180683
Alternate JournalJ. Alzheimers Dis.
PubMed ID30475766
PubMed Central IDPMC6301117
Grant ListR01 AG047649 / AG / NIA NIH HHS / United States
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Source URL: https://www.j-alz.com/content/utility-amyloid-pet-scans-evaluation-patients-presenting-diverse-cognitive-complaints