Title | TDP-43 Neuropathologic Associations in the Nun Study and the Honolulu-Asia Aging Study. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Flanagan, ME, Cholerton, B, Latimer, CS, Hemmy, LS, Edland, SD, Montine, KS, White, LR, Montine, TJ |
Journal | J Alzheimers Dis |
Volume | 66 |
Issue | 4 |
Pagination | 1549-1558 |
Date Published | 2018 |
ISSN | 1875-8908 |
Abstract | Transactive response binding protein-43 (TDP-43) cytoplasmic neuronal and glial aggregates (pathologic TDP-43) have been described in multiple brain diseases. We describe the associations between neuropathologically confirmed TDP-43 and cognition in two population-based cohorts: the Nun Study (NS) and the Honolulu-Asia Aging Study (HAAS). In the HAAS, there was a significant association between hippocampal sclerosis (HS) and TDP-43 (OR = 11.04, p 0.001 95%, CI 7.10-38.00) and Alzheimer's disease (AD) severity (OR = 1.74, p = 0.009, 95% CI 1.15-2.64). When cognitive scores were added to the model, HS remained significant but the other variables were not. When HS was removed from the model, the overall model remained significant and the associations between cognitive performance and TDP-43 (OR = 2.11, p = 0.022, 95% CI 1.11-4.02) were significant. In the NS, there was a significant association between cognitive performance and TDP-43 (OR 1.94 p = 0.005, 95% CI 1.22-3.09) (HS remained significant, but AD did not). When HS was removed from the model, only CERAD was significant (OR = 2.43 p |
DOI | 10.3233/JAD-180162 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 30452409 |
Grant List | UF1 AG053983 / AG / NIA NIH HHS / United States P50 AG005136 / AG / NIA NIH HHS / United States U01 AG019349 / AG / NIA NIH HHS / United States U01 AG046871 / AG / NIA NIH HHS / United States UF1 AG057707 / AG / NIA NIH HHS / United States P50 NS062684 / NS / NINDS NIH HHS / United States U01 AG017155 / AG / NIA NIH HHS / United States P50 AG047366 / AG / NIA NIH HHS / United States |