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Home > Non-Phosphorylated Tau in Cerebrospinal Fluid is a Marker of Alzheimer's Disease Continuum in Young Urbanites Exposed to Air Pollution.

TitleNon-Phosphorylated Tau in Cerebrospinal Fluid is a Marker of Alzheimer's Disease Continuum in Young Urbanites Exposed to Air Pollution.
Publication TypeJournal Article
Year of Publication2018
AuthorsCalderón-Garcidueñas, L, Mukherjee, PS, Waniek, K, Holzer, M, Chao, C-K, Thompson, C, Ruiz-Ramos, R, Calderón-Garcidueñas, A, Franco-Lira, M, Reynoso-Robles, R, González-Maciel, A, Lachmann, I
JournalJ Alzheimers Dis
Volume66
Issue4
Pagination1437-1451
Date Published2018
ISSN1875-8908
Abstract

Long-term exposure to fine particulate matter (PM2.5) and ozone (O3) above USEPA standards is associated with Alzheimer's disease (AD) risk. Metropolitan Mexico City (MMC) children exhibit subcortical pretangles in infancy and cortical tau pre-tangles, NFTs, and amyloid phases 1-2 by the 2nd decade. Given their AD continuum, we measured in 507 normal cerebrospinal fluid (CSF) samples (MMC 354, controls 153, 12.82±6.73 y), a high affinity monoclonal non-phosphorylated tau antibody (non-P-Tau), as a potential biomarker of AD and axonal damage. In 81 samples, we also measured total tau (T-Tau), tau phosphorylated at threonine 181 (P-Tau), amyloid-β1-42, BDNF, and vitamin D. We documented by electron microscopy myelinated axonal size and the pathology associated with combustion-derived nanoparticles (CDNPs) in anterior cingulate cortex white matter in 6 young residents (16.25±3.34 y). Non-P-Tau showed a strong increase with age significantly faster among MMC versus controls (p = 0.0055). Aβ1 - 42 and BDNF concentrations were lower in MMC children (p = 0.002 and 0.03, respectively). Anterior cingulate cortex showed a significant decrease (p = 

DOI10.3233/JAD-180853
Alternate JournalJ. Alzheimers Dis.
PubMed ID30412505
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Source URL: https://www.j-alz.com/content/non-phosphorylated-tau-cerebrospinal-fluid-marker-alzheimers-disease-continuum-young