Title | Cognitive Impairment is Associated with Mortality in Hemodialysis Patients. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Angermann, S, Schier, J, Baumann, M, Steubl, D, Hauser, C, Lorenz, G, Günthner, R, Braunisch, MC, Kemmner, S, Satanovskij, R, Haller, B, Heemann, U, Lehnert, T, Bieber, R, Pachmann, M, Braun, J, Scherf, J, Schätzle, G, Fischereder, M, Grimmer, T, Schmaderer, C |
Journal | J Alzheimers Dis |
Volume | 66 |
Issue | 4 |
Pagination | 1529-1537 |
Date Published | 2018 |
ISSN | 1875-8908 |
Abstract | BACKGROUND: The prevalence of cognitive impairment in hemodialysis patients is notably high. In previous studises performed in the general population, cognitive impairment has been associated with increased mortality. OBJECTIVE: We evaluated the relationship between global cognitive function tested by a short screening instrument and mortality in hemodialysis patients. METHODS: Cognitive testing was performed in 242 maintenance hemodialysis patients under standardized conditions at baseline using the Montreal Cognitive Assessment (MoCA).Cognitive impairment was defined as a MoCA test score ≤24 points, as published previously. All-cause mortality was monitored during a median follow-up of 3.54 years. Kaplan-Meier plot and Cox regression model adjusted for known risk factors for mortality in hemodialysis patients were used to examine a possible association between global cognitive function and all-cause mortality. RESULTS: A MoCA test score ≤24 points resulted in a significant almost 3-fold higher hazard for all-cause mortality (unadjusted hazard ratio [HR]: 2.812; 95% confidence interval [95% CI]: 1.683-4.698; p CONCLUSION: Impairment of global cognitive function measured by a short screening instrument was identified for the first time as an independent predictor of all-cause mortality in hemodialysis patients. Thus, implementing the MoCA test in clinical routine could contribute to a better risk stratification of this patient population. |
DOI | 10.3233/JAD-180767 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 30412499 |