The Alzheimer’s Funding Analyzer (AFA) showcases funding distribution from 42 countries and allows the end-user to conduct line-of-investigation queries to look for funding trends.
ApoE4 and apoE3 astrocytes, transiently transfected with LC3-GFP vector, were starved (EBSS for 1 h) in the presence and absence of 10 µM chloroquine (CQ). The cells were then fixed, stained (Hoechst 33258) and photographed (scale bars, 10 µm). From Simonovitch et al., JAD51(3).
AβPP and nicastrin (NCT) were associated under normal conditions. However, after AY9944 treatment, AβPP and NCT were no longer colocalized. Scale bar = 15 μm. From Kim et al., JAD51(4).
Accumulation of Amyloid-β (green), the unmodified N-terminus (red), and the conformational change in the N-terminus of TauP301L (blue) in the hippocampal formation of the 28-month-old 3×Tg-AD transgenic mouse. Scale bar, 100 μm. From Ontiveros-Torres et al., JAD52(1).
Neurovascular trophic coupling change with an increase of inner diameter of parenchymal vessels, morphological change of vascular endothelial cells, and a decreased BDNG expression in endothelia in APP23+CCH (chronic cerebral hypoperfusion) model. From Shang et al., JAD52(1)
Amyloid plaques in Tg2576 mice, stained by 4G8 antibody (G1), are associated with nanoparticles containing ICG dye (G2) and ET6-21 ligand (G3); G4 shows overlay. Higher magnification (60X) (H1H4) shows colocalization of nanoparticles within single plaque. From Tanifum et al., JAD 52(2).
Positive striatal [18F]flutemetamol PET signal (right panel), with MR images for orientation (left panel). Arrows indicate position of striatum (head of caudate nucleus and putamen). From Beach et al., JAD52(3).
Predicted structures of the human presenilin 1 protein and the orthologous presenilin B protein from the social amoeba Dictyostelium discoideum suggests conserved function. From Otto, Sharma, and Williams, JAD52(4).
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