LATEST JAD EDITORS’ BLOG I eat, therefore I am a nutrition expert by Martha Clare Morris, ScD
The 2016 Alzheimer Award goes to Mark Bondi for "Subtle Cognitive Decline and Biomarker Staging in Preclinical Alzheimer's Disease." For more information, click here or go to http://www.j-alz.com/award.
The Journal of Alzheimer's Disease
is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease.
We applied bibliometric analytics to identify 300 highly cited papers relevant to AD research, published in the last 5 years. Members voted for their top 10 most influential papers. See the results!
The Alzheimer’s Funding Analyzer (AFA) showcases funding distribution from 42 countries and allows the end-user to conduct line-of-investigation queries to look for funding trends.
In the delayed-match-to-sample task, mild cognitive impairment patients (MCI) showed reduced repetition-driven suppression in the occipital brain regions relative to normal controls (NC). Activation is in red and deactivation is in blue. From Yu et al., JAD53(2).
Changes in Claudin-5 expression (green) after treatment with selected FDA approved drugs demonstrate their repurposing potential to rectify compromised blood-brain barrier integrity in Alzheimer's disease and CAA (scale bar = 50 µm). From Qosa et al., JAD53(4).
Cell-type composition of primary mixed cultures (MIX-S). Approximately 56% and 44% of the MIX-S were made up of neurons identified by NeuN and Tuj1 (red) and astrocytes identified by GFAP (green), respectively; Hoechst 33342 was used to mark nuclei (blue). From Li et al., JAD54(1).
Effect of paired helical filament (PHF) in altering dynein localization (marked in red/with arrows), near the pericentrin-positive centrosome (marked in magenta). PHF promotes tau aggresomes in GFP-tagged human tau expressing human embryonic kidney cells. From Varghese et al., JAD54(2).
Oleuropein aglycone (OLE), the main polyphenol found in the olive oil, inhibits poly(ADP-ribose) (PAR) polymers formation in the brain of TgCRND8 mice (Tg OLE). Double immunofluorescence with NeuN (red) and PAR (green) antibody plus DAPI (blue). From Luccarini et al., JAD54(2).
Immunofluorescence of the cerebellum tissue of males and females. Amyloid plaques in red signed with arrows, GFAP in green and DAPI in blue. ML (molecular layer), GL (granular layer). From Ordoñez-Gutierrez et al., JAD54(2).
Uptake of DiI-acetylated low density lipoprotein by adult human microglia in low (left) and high (right) passage cultures. From Guo et al., JAD54(3).
Fluorescent co-labelling of oligomeric tau (T22) with total tau (Tau5) in hippocampal tissue 6 months post injection with transgenic rTg4510 lysate. Scale bar = 200 µm. (i), 20 µm (ii,iii). From Baker et al., JAD54(3).
Also of interest:
Journal of Huntington's Disease Journal of Neuromuscular Diseases Journal of Parkinson's Disease