Cell-type composition of primary mixed cultures (MIX-S). Approximately 56% and 44% of the MIX-S were made up of neurons identified by NeuN and Tuj1 (red) and astrocytes identified by GFAP (green), respectively; Hoechst 33342 was used to mark nuclei (blue). From Li et al., JAD54(1).
Effect of paired helical filament (PHF) in altering dynein localization (marked in red/with arrows), near the pericentrin-positive centrosome (marked in magenta). PHF promotes tau aggresomes in GFP-tagged human tau expressing human embryonic kidney cells. From Varghese et al., JAD54(2).
Oleuropein aglycone (OLE), the main polyphenol found in the olive oil, inhibits poly(ADP-ribose) (PAR) polymers formation in the brain of TgCRND8 mice (Tg OLE). Double immunofluorescence with NeuN (red) and PAR (green) antibody plus DAPI (blue). From Luccarini et al., JAD54(2).
Immunofluorescence of the cerebellum tissue of males and females. Amyloid plaques in red signed with arrows, GFAP in green and DAPI in blue. ML (molecular layer), GL (granular layer). From Ordoñez-Gutierrez et al., JAD54(2).
The Alzheimer’s Funding Analyzer (AFA) showcases funding distribution from 42 countries and allows the end-user to conduct line-of-investigation queries to look for funding trends.
Uptake of DiI-acetylated low density lipoprotein by adult human microglia in low (left) and high (right) passage cultures. From Guo et al., JAD54(3).
Fluorescent co-labelling of oligomeric tau (T22) with total tau (Tau5) in hippocampal tissue 6 months post injection with transgenic rTg4510 lysate. Scale bar = 200 µm. (i), 20 µm (ii,iii). From Baker et al., JAD54(3).
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A polyphenolic extract from blueberries and grapes had no obvious effect on neurofibrillary tangles in the hippocampus of 16 month-old 3xTg-AD mice after a 4-month supplementation. From Dal-Pan et al., JAD55(1).
Confocal micrograph of rat primary hippocampal culture neurons shows that synaptophysin (green) expressed in the synapses and TREM2 (red) was present membrane bound, perinuclear location and visible axon and dendrites. Taken from Raha et al., JAD55(1).
In rats, i.c. STZ caused hippocampal atrophy with neuronal loss and white matter (wm) degeneration [B, E] relative to control [A, D]. T3D-959 prevented these i.c. STZ effects [C, F], restoring downstream insulin/IGF signaling and reducing neuro-inflammation. From de la Monte et al., JAD55(2).
The interplay between tau oligomers and inflammation in the brain and retina. Tau oligomers (red), microglia (green), and nuclei (blue) in the P301L tau transgenic mouse retina which may be a window to brain pathology. From Nilson et al., JAD55(3).
9-month-old APPswe/PS1dE9 mice brains were stained with anti-CD11b (green; b) or anti-GFAP (green; d) and anti-suppressor of cytokine signaling (anti-SOCS3) (red). SOCS3 expressed on glial cells in APPswe/PS1dE9 mice mouse cortex. From Iwahara et al., JAD55(3).