Genetic deletion of TNF-α results in reduced Thioflavine S-positive amyloid plaque load and decreased plaque-associated microglial (Iba1) and astrocytic (GFAP) activation in the cortex and the subiculum of the hippocampus of 4-month-old 5XFAD mice. From Paouri et al., JAD60(1).
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Immunofluorescence stainings of control cultures and cultures exposed to Aβ42 protofibrils show a vesicular expression pattern of Apolipoprotein E (apoE) (red) close to the plasma membrane of astrocytes (green) following Aβ treatment. From Nikitidou et al., JAD60(1).
The 2017 Alzheimer Award goes to Shi-Jiang Li for "Staging Alzheimer's Disease Risk by Sequencing Brain Function and Structure, Cerebrospinal Fluid, and Cognition Biomarkers". For more information, click here or go to www.j-alz.com/award.
Immunofluorescence staining showed that Dkk3 (red) expression was significantly decreased in AD mice and increased in Dkk3 and Dkk3×AD mice. Double-ﬂuorescent staining indicated that Dkk3 (red) was mainly localized to the neurons rather than the astrocytes (green). From Zhang et al., JAD60(2).
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Images taken from Grasp 65 (green)/AT8 (red) double immunostained sections from somatosensory cortex of P301S mice showing the alterations of the Golgi apparatus in AT8+ neurons (right) as compared with AT8- neurons (left). From Antón-Fernández et al., JAD60(2).
Increases in astrocytes (GFAP) are reduced toward nontransgenic levels with pazopanib treatment in TauP301L mice. From Javidnia et al., JAD60(2).
Phospho-tau immunostaining with AT-8 antibody in the cortex and hippocampus of wild type mice with normal feed (NFWT), with curcumin-containing feed (CFWT) and p25 transgenic mice with normal feed (NFBT) and curcumin containing feed (CFBT). From Sundaram et al., JAD60(4).
Double immunofluorescent labeling of the occipital cortex of AD cases with capCAA confirmed the expression of ASM by microglia (left panel) and ceramide by astrocytes (right panel). From de Wit et al., JAD60(3).