The 2017 Alzheimer Award goes to Shi-Jiang Li for "Staging Alzheimer's Disease Risk by Sequencing Brain Function and Structure, Cerebrospinal Fluid, and Cognition Biomarkers". For more information, click here or go to www.j-alz.com/award.
The Journal of Alzheimer's Disease
is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease.
JAD Reports is a new international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease.
Magnetic resonance images of edematous amyloid-related imaging abnormalities (ARIA-E; arrows) in the brain of an aged squirrel monkey with severe cerebral amyloid angiopathy. From Heuer et al., JAD57(2).
Images of probable CAA show that regions with cerebral microbleeds or cortical superficial siderosis (seen on T2* MRI) largely overlapped with those showing increased AV1451 uptake. From Kim et al., JAD 57(3).
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Resting-state functional MRI maps of the salience network (blue) and default mode network (red) in a healthy adult. Correspondence with targets of non-invasive brain stimulation (white circles) was evaluated with stereotactic markers (fish oil capsules). From Pievani et al., 57(3).
BV2 microglial cells transfected with mCherry-GFP-LC3 showed that orexin, a major sleep modulator, suppressed microglial clearance of amyloid-β by interfering with the autophagosome-lysosome fusion process. From An et al., JAD58(1)
Double anti-tau (AT8, green) and anti-Aβx-40 (red) immunofluorescent staining. Labeling do not co-localize in the neuronal profiles (merged in C) suggesting two separate neurodegenerating populations in AD brains. From Lacosta et al., JAD58(3).
Endogenous intracellular tau in primary mouse neurons aggregates after the cells are exposed to extracellular oligomers, but neither monomers nor filaments made from human 2N4R tau. From Swanson et al., JAD58(3).