Chronic hypoxia accelerates AD neuropathology in Tg mice. 6E10 staining of plaques in the hippocampus of Tg mice. There were more and larger plaques in hypoxia-treated Tg mice than age-matched controls. Image taken from Liu et al., JAD48(4).
Cultured astrocytes were treated with Aβ (A,C) or the scrambled peptide (B,D) and Brefeldin A (BFA; C,D), and immunostained for HspB1. Aβ-induced HspB1 release was unaffected by BFA, suggesting it does not involve conventional protein secretory pathway(s). From Nafar et al., JAD 49(1).
Fluorescence-immunostaining in AD cases. Whereas 4G8 shows abundant staining of CAA and extracellular amyloid plaques (A), pAb77 labeling is mainly restricted to vascular deposits (B-F). Image taken from Savastano et al., JAD49(1).
Retinal oxygen saturation in arterioles and venules in patients with moderate AD was significantly elevated compared to healthy individuals. Noninvasive retinal oximetry may offer new insights into pathophysiology of AD. Image taken from Einarsdottir et al., JAD49(1).
Using J20 mice, we found that neurons participating in the mouse olfactory function overexpress AβPP. In contrast, neither widespread Aβ deposition nor microglia aggregates are prevalent in the J20 olfactory bulb. Image taken from Rusznák et al., JAD49(2).
Immunofluorescent analysis to explore the co-localization of phosphorylated tau (red) and ß sheet aggregates (green) in control and LDN treated cells. The nuclei were stained with Hoechst (blue). Scale bar, 20 μm. Image taken from Xie et al., JAD49(2).
White matter changes are prevalent in Alzheimer's disease (AD) and were linked to classical markers of AD such as ventricular and hippocampal volumes. Studying these changes may lead to a better understanding of AD pathophysiology. Taken from Coutu et al., JAD49(2).
The interaction between PrPc (red) and LRP/LR (green) facilitates a role for LRP/LR in Aβ induced cytotoxicity. Antibody blockage or downregulation of LRP/LR reduces Aβ induced cytotoxicity but only in the presence of PrPc. Image taken from Pinnock et al., JAD49(3).
Also of interest:
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