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de la TorreBook and manNFTshippocampal_cultureAlzheimer’s Funding AnalyzerSTZretinaOther JournalsSOCS3TOTOcholesterolACI-5400amyloidcortical neuronshippocampal CA1

LATEST JAD EDITORS’ BLOG
What is wrong with Alzheimer’s disease clinical research?
by Jack de la Torre, MD, PhD

The Journal of Alzheimer's Disease

is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease.

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A polyphenolic extract from blueberries and grapes had no obvious effect on neurofibrillary tangles in the hippocampus of 16 month-old 3xTg-AD mice after a 4-month supplementation. From Dal-Pan et al., JAD55(1).

Confocal micrograph of rat primary hippocampal culture neurons shows that synaptophysin (green) expressed in the synapses and TREM2 (red) was present membrane bound, perinuclear location and visible axon and dendrites. Taken from Raha et al., JAD55(1).

The Alzheimer’s Funding Analyzer (AFA) showcases funding distribution from 42 countries and allows the end-user to conduct line-of-investigation queries to look for funding trends.

In rats, i.c. STZ caused hippocampal atrophy with neuronal loss and white matter (wm) degeneration [B, E] relative to control [A, D]. T3D-959 prevented these i.c. STZ effects [C, F], restoring downstream insulin/IGF signaling and reducing neuro-inflammation. From de la Monte et al., JAD55(2).

The interplay between tau oligomers and inflammation in the brain and retina. Tau oligomers (red), microglia (green), and nuclei (blue) in the P301L tau transgenic mouse retina which may be a window to brain pathology. From Nilson et al., JAD55(3).

Also of interest:

 

Journal of Huntington's Disease
Journal of Neuromuscular Diseases
Journal of Parkinson's Disease

 

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9-month-old APPswe/PS1dE9 mice brains were stained with anti-CD11b (green; b) or anti-GFAP (green; d) and anti-suppressor of cytokine signaling (anti-SOCS3) (red). SOCS3 expressed on glial cells in APPswe/PS1dE9 mice mouse cortex. From Iwahara et al., JAD55(3).

Senile plaques (X-34) were surrounded by glial neuro-inflammatory reactions (GFAP- & Iba1) in the hippocampus of AβPPswe/PSEN1dE9 transgenic mice. Rivastigmine treatment blocked these inflammatory reactions. From Matsuda and Hisatsune, JAD56(1).

Fluorescent staining of estrogen receptor alpha (ERα) in green and DAPI (blue) in hippocampal tissue of rabbits fed a high-cholesterol diet. From Brooks et al., JAD56(1).

The pTau antibody ACI-5400 staining of somata and apical dendrites of pyramidal neurons in CA1 and in cortex coincided with that of MC1 (B, green), whereas staining with a control pS396 antibody additionally stained non-tangled neurons (C, red). From Theunis et al., JAD56(2).

Analysis for abnormal amyloid-beta metabolism. Accumulation of amyloid-beta granules is clearly seen in cultures of neurons with Down syndrome. Staining for Abeta-42 (red) and beta-III-tubulin (green); cell nuclei were counterstained with DAPI (blue). From Dashinimaev et al., JAD56(2).

Mouse primary cortical neurons were subjected to immunocytochemistry using type III β-tubulin (red) and synaptotagmin (green) as the primary antibodies. The same fields were stained with DAPI (blue) and merged. From Lin et al., JAD56(3).

Treadmill exercise markedly attenuated STZ-induced neuronal degeneration in hippocampal CA1, as evidenced by a lower level of F-Jade C staining (green). From Lu et al., JAD56(4).

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The Journal of Alzheimer's Disease is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease.

JAD has an Impact Factor of 3.920 (2016 Journal Citation Reports), an h-index of 77 (Web of Science), an h-index of 85 (SCImago Journal Rank indicator), an h5-index of 67 (Google Scholar), and an h5-median of 83 (Google Scholar).

 

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