I have read with interest the recent report by Jin and coworkers on the putative role of SORL1 variants in sporadic Alzheimer’s disease .
PSP-like Features without PSP Cytopathology in Three Cases of Alzheimer’s Disease/Parkinson’s Disease
Two studies published in the Journal of Alzheimer’s Disease indicate that some of the pathologic changes associated with Alzheimer’s disease in older individuals are not apparent in young people who carry the apolipoprotein (APOE) genetic risk factor for developing the disease.
JAD has launched a new feature, “Ethics Review,” which will provide support and guidance to move ethical decision-making forward. The goal is to create a forum for dementia researchers, clinicians and policy makers to bring greater clarity and constructive discussion to define risks and benefits from the perspectives of diverse disciplines.
A team from the University of California, San Diego School of Medicine, the Medical University of South Carolina and San Diego-based American Life Science Pharmaceuticals, Inc., report that cathepsin B gene knockout or its reduction by an enzyme inhibitor blocks creation of key neurotoxic pGlu-Aβ peptides linked to Alzheimer’s disease.
Researchers studying peptides using the Gordon supercomputer at the San Diego Supercomputer Center (SDSC) at the University of California, San Diego (UCSD) have found new ways to elucidate the creation of the toxic oligomers associated with Alzheimer’s disease.
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