Uptake of DiI-acetylated low density lipoprotein by adult human microglia in low (left) and high (right) passage cultures. From Guo et al., JAD54(3).
Fluorescent co-labelling of oligomeric tau (T22) with total tau (Tau5) in hippocampal tissue 6 months post injection with transgenic rTg4510 lysate. Scale bar = 200 µm. (i), 20 µm (ii,iii). From Baker et al., JAD54(3).
The Alzheimer’s Funding Analyzer (AFA) showcases funding distribution from 42 countries and allows the end-user to conduct line-of-investigation queries to look for funding trends.
A polyphenolic extract from blueberries and grapes had no obvious effect on neurofibrillary tangles in the hippocampus of 16 month-old 3xTg-AD mice after a 4-month supplementation. From Dal-Pan et al., JAD55(1).
Confocal micrograph of rat primary hippocampal culture neurons shows that synaptophysin (green) expressed in the synapses and TREM2 (red) was present membrane bound, perinuclear location and visible axon and dendrites. Taken from Raha et al., JAD55(1).
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In rats, i.c. STZ caused hippocampal atrophy with neuronal loss and white matter (wm) degeneration [B, E] relative to control [A, D]. T3D-959 prevented these i.c. STZ effects [C, F], restoring downstream insulin/IGF signaling and reducing neuro-inflammation. From de la Monte et al., JAD55(2).
The interplay between tau oligomers and inflammation in the brain and retina. Tau oligomers (red), microglia (green), and nuclei (blue) in the P301L tau transgenic mouse retina which may be a window to brain pathology. From Nilson et al., JAD55(3).
9-month-old APPswe/PS1dE9 mice brains were stained with anti-CD11b (green; b) or anti-GFAP (green; d) and anti-suppressor of cytokine signaling (anti-SOCS3) (red). SOCS3 expressed on glial cells in APPswe/PS1dE9 mice mouse cortex. From Iwahara et al., JAD55(3).
Senile plaques (X-34) were surrounded by glial neuro-inflammatory reactions (GFAP- & Iba1) in the hippocampus of AβPPswe/PSEN1dE9 transgenic mice. Rivastigmine treatment blocked these inflammatory reactions. From Matsuda and Hisatsune, JAD56(1).
Fluorescent staining of estrogen receptor alpha (ERα) in green and DAPI (blue) in hippocampal tissue of rabbits fed a high-cholesterol diet. From Brooks et al., JAD56(1).
Analysis for abnormal amyloid-beta metabolism. Accumulation of amyloid-beta granules is clearly seen in cultures of neurons with Down syndrome. Staining for Abeta-42 (red) and beta-III-tubulin (green); cell nuclei were counterstained with DAPI (blue). From Dashinimaev et al., JAD56(2).
The pTau antibody ACI-5400 staining of somata and apical dendrites of pyramidal neurons in CA1 and in cortex coincided with that of MC1 (B, green), whereas staining with a control pS396 antibody additionally stained non-tangled neurons (C, red). From Theunis et al., JAD56(2).